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PF-46396 is a HIV maturation inhibitor. PF-46396 displayed potent activity against HIV-1 clade B. PF-46396 as a broadly active maturation inhibitor can be used against HIV-1 clade B and C and help in rational designing of novel analogs with reduced toxicity and increased efficacy for its potential use in clinics.

PF-46396 is a potent HIV-1 inhibitor with an EC50 value of 0.206 μM. PF-46396 shows antiviral activity. PF-46396 inhibits the processing of capsid (CA)/spacer peptide 1 (SP1) (p25) Gag precursor proteins and blocks maturation of the viral core particle[1].

HIV-1: 0.206 μM (EC₅₀)

[1] Blair WS, et al . New small-molecule inhibitor class targeting human immunodeficiency virus type 1 virion maturation. Antimicrob Agents Chemother. 2009 Dec;53(12):5080-7. DOI:10.1128/AAC.00759-09