1204669-37-3

ido inhibitor 1 is a potent and novel indoleamine-2,3 dioxygenase (ido) inhibitor with ic50 value <100 nm.ido is an enzyme that catalyzes the degradation of the essential amino acid l-tryptophan to n-formylkynurenine and permits tumor cells to escape the immune system.

[1]. andrew p. combs, et al. 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase. patent numeber: ep 2315756 a2http://www. google.com/patents/ep2315756a2?cl=en