ChemicalBook CAS DataBase List 119188-33-9

119188-33-9

Name	Coronarin A
CAS	119188-33-9
Molecular Formula	C20H28O2
MDL Number	MFCD17214879
Molecular Weight	300.44
MOL File	119188-33-9.mol

Chemical Properties

Melting point	100-102 °C(Solvent: Hexane)
Boiling point	401.122±40.00 °C(Press: 760.00 Torr)(predicted)
density	1.053±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
form	Solid
pka	14.632±0.70(predicted)
color	White to off-white

Hazard Information

Uses

Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research[1].

in vivo

Coronarin A (30 or 100 mg/kg; i.p. or p.o.; once daily for 22 days) ameliorates hyperglycemia in mice^[1].
Coronarin A (100 mg/kg; p.o.; once daily for 22 days) inhibits the mTOR/S6K1 pathway to activate PI3K/Akt and ERK/β-catenin signaling in livers of ob/ob mice^[1].
Pharmacokinetic properties of Coronarin A after single administration^a in ob/ob mice^[1].

Coronarin A	t_1/2 (h)	t_max (h)	C_max (ng/mL)	AUC_0-t (ng·h/mL)	AUC_0-∞ (ng·h/mL)	MRT (h)
i.p.	14.8	1.0	1073	4571	11045	21.7
p.o.	3.01	1.0	388	1694	1856	4.88

Data are presented as the mean of three mice.
^aCoronarin A was intraperitoneally or orally administered at 30 mg/kg to ob/ob mice.

Animal Model:	Male ob/ob mice^[1]
Dosage:	30 mg/kg (IP) or 100 mg/kg (PO)
Administration:	Oral or intraperitoneal administration, once daily for 22 days
Result:	Significantly decreased the non-fasting and fasting blood glucose. Significantly reduced the serum insulin concentration at 15 min after glucose loading, reduced the average daily food intake while the body weight was unaffected. Increased hepatic glycogen content and the expression levels of gluconeogenic gene Pck1 and G6pc were significantly decreased.

Animal Model:	Female ob/ob mice^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal or oral administration (Pharmacokinetic Analysis)
Result:	Intraperitoneal injection exhibited higher plasma exposure than oral gavage at the same dose of 30 mg/kg, with C_max value of 1073 and 388 ng/mL, respectively.

IC 50

mTORC1; S6K1

References

[1] Huang SL, et al. Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice. Acta Pharmacol Sin. 2022 Sep 9. DOI:10.1038/s41401-022-00985-5

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