Spermine(N3BBB) is a click chemistry reagent containing an azide group and can be used for various biochemical studies[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
References
[1] Roeland Vanhoutte, et al. Clickable Polyamine Derivatives as Chemical Probes for the Polyamine Transport System. Chembiochem. 2018 May 4;19(9):907-911. DOI:10.1002/cbic.201800043
