ChemicalBook CAS DataBase List 119-38-0

119-38-0

Name	Isolan powder(content2%-20%)
CAS	119-38-0
EINECS(EC#)	204-318-2
Molecular Formula	C10H17N3O2
Molecular Weight	211.261
MOL File	119-38-0.mol

Synonyms

Saolan G-23611 ISOLANE IsolanR ENT-19060 Primin powder Primin emulsion RNNBHZYEKNHLKT-UHFFFAOYSA-N Isolan powder(content2%-20%) Isolan emulsion(content0.5%-20%) 1-isopropyl-3-methylpyrazol-5-yl dimethylcarbamate Isopropylmethylpyrazolyl dimethylcarbamate: (Isolan) DIMETHYLCARBAMICACID-1-ISOPROPYL-3-METHYLPYRAZOLE-5-YL 1-isopropyl-3-methylpyrazol-5-yl dimethylcarbamate isolan (5-methyl-2-propan-2-ylpyrazol-3-yl) N,N-dimethylcarbamate (5-methyl-2-propan-2-yl-pyrazol-3-yl) N,N-dimethylcarbamate N,N-Dimethylcarbamic acid 1-isopropyl-3-methyl-1H-pyrazol-5-yl N,N-dimethylcarbamic acid (2-isopropyl-5-methyl-pyrazol-3-yl) ester N,N-Dimethylcarbamic acid 1-isopropyl-3-methyl-1H-pyrazol-5-yl ester Carbamicacid,dimethyl-,3-methyl-1-(1-methylethyl)-1H-pyrazol-5-ylester Carbamic acid, N,N-dimethyl-, 3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl ester

Chemical Properties

Appearance	Liquid. Miscible with water.
Boiling point	bp0.7 103°; bp2.5 117.5-118°
density	1.07
refractive index	1.4830 (estimate)
Henry's Law Constant	4.9×10³ mol/(m³Pa) at 25℃, HSDB (2015)
InChI	1S/C10H17N3O2/c1-7(2)13-9(6-8(3)11-13)15-10(14)12(4)5/h6-7H,1-5H3
SMILES	CC(C)N1C(OC(N(C)C)=O)=CC(C)=N1
CAS DataBase Reference	119-38-0
EPA Substance Registry System	Isolane (119-38-0)

Safety Data

Hazard Codes	T+
Risk Statements	27/28 less more
Safety Statements	28-36/37/39-45 less more
RIDADR	2992
WGK Germany	WGK 3
HazardClass	6.1(a)
PackingGroup	I
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 1 Dermal Acute Tox. 2 Oral
Safety Profile	Poison by ingestion, skin contact, and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. An insecticide. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES less more
Hazardous Substances Data	119-38-0(Hazardous Substances Data)
Toxicity	LD50 in male, female rats (mg/kg): 23, 13 orally; 5.6, 6.2 dermally (Gaines, 1969) less more

Hazard Information

Chemical Properties

Liquid. Miscible with water.

Uses

Insecticide.

General Description

Colorless liquid. Used as a systemic aphicide in Europe, insecticide. Currently of little commercial interest. Not registered as a pesticide in the U.S.

Reactivity Profile

Isolan powder(content2%-20%) is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.

Health Hazard

Isolan powder(content2%-20%) is classified as extremely toxic. Probable oral lethal dose in humans is 5-50 mg/kg or between 7 drops and 1 teaspoonful for a 150-lb. person. A cholinesterase inhibitor; although it is not an organic phosphate, it resembles that group in action.

Fire Hazard

When heated to decomposition, Isolan powder(content2%-20%) emits toxic fumes of nitrogen oxides.

Hazard

Cholinesterase inhibitor.

Production Methods

The commercial production of isolan involves the synthesis of the pyrazole ring followed by carbamoylation using dimethylcarbamoyl chloride or a similar reagent. The process typically includes condensation of isopropylhydrazine with methyl ethyl ketone to form the substituted pyrazole, which is then esterified with dimethylcarbamic acid derivatives. The final product is purified through distillation or crystallisation.

Mechanism of action

Systemic. Acetylcholinesterase (AchE) inhibitor.

Pesticide Type

Insecticide

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