1173021-73-2

Salbutamol-d₉ is intended for use as an internal standard for the quantification of salbutamol (Item Nos. 21003 | 23991) by GC- or LC-MS. Salbutamol is an agonist of the β₂-adrenergic receptor (β₂-AR; K_d = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor). It is selective for β₂-ARs over β₁- and β₃-ARs (K_ds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs. It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC₅₀ = 39.7 μg). Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Off-White to Pale Yellow Solid

A labeled ?-adrenoceptor agonist

A labelled β2-adrenoceptor agonist. Bronchodilator; tocolytic.

RAC ALBUTEROL-D9 is a labelled β2-adrenoceptor agonist,it is intended for use as an internal standard for the quantification of Albuterol by GC- or LC-mass spectrometry.

Store at -20°C

[1] CHRISTOPHER KERN. Synthesis and Pharmacological Characterization of β2-Adrenergic Agonist Enantiomers: Zilpaterol[J]. Journal of Medicinal Chemistry, 2009, 52 6: 1773-1777. DOI: 10.1021/jm801211c
[2] BAKER J G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors[J]. British Journal of Pharmacology, 2009, 144 3: 317-322. DOI: 10.1038/sj.bjp.0706048
[3] VALERIE A. CULLUM. Salbutamol: a new, selective β-adrenoceptive receptor stimulant[J]. British Journal of Pharmacology, 1969, 35 1: 141-151. DOI: 10.1111/j.1476-5381.1969.tb07975.x
[4] M.G. ARROYO. Efficacy of Inhaled Levalbuterol Compared to Albuterol in Horses with Recurrent Airway Obstruction[J]. Journal of Veterinary Internal Medicine, 2016, 30 4: 1333-1337. DOI: 10.1111/jvim.14320