1159822-10-2

A mixture of 2-bromo-6-(tetrahydrofuran-3-yl)pyridine (1.24 g), TEA (661.26 mg), and Pd(dppf)Cl2 (199.23 mg) in MeOH (100 mL) was heated at 110°C for 24 hours under CO atmosphere. The reaction mixture was concentrated, and the residue was suspended in MTBE and filtered through a silica gel pad. The filtrate was evaporated to give methyl 6-(tetrahydrofuran-3-yl)picolinate (400 mg, 35.42% yield) as a reddish oil.