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ML358 is a selective inhibitor of SKN-1 pathway involved in drug detoxification and resistance in nematodes.

ML358 is a first in class, potent, and selective inhibitor of the SKN-1 pathway (IC50=0.24 μM). ML358 sensitizes the model nematode C. elegans to oxidants and anthelmintic. ML358 potentially used as adjuvants to increase the efficacy and useful life of current anthelmintics[1].

[1] Peddibhotla, S, et al.?Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes. ACS Chemical Biology, 10(8), 1871–1879. DOI:10.1021/acschembio.5b00304