1146963-51-0

J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.

ChEBI: J147 is an anilide.

J 147 improves heart health by lowering blood pressure, boosts metabolism, supports digestive and immune system function, improves cognitive function, has no side effects, and increases physical strength with long-term use. Once there is significant weight loss after taking it, this supplement helps people maintain their weight by reducing cravings and increasing energy levels. Since it helps suppress the hunger hormone that causes overeating, people who use J147 capsules for a long time are more likely to maintain their weight

J 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.

Trifluoroacetic anhydride (0.33 mL, 2.36 mmol) was added slowly and dropwise to a stirred solution of 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide (500 mg, 1.97 mmol) and triethylamine (0.33 mL, 2.36 mmol) in dichloromethane (5 mL) at 0 °C and under nitrogen protection. The reaction mixture was stirred continuously at 0°C for 1.5 hours. Upon completion of the reaction, the mixture was concentrated and the residue was purified by column chromatography using acetone/hexane (1:10) as eluent to afford the target product 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylidene]hydrazide (571 mg, 83% yield) as a light yellow oil.1H NMR (CDCl3) data were as follows: δ7.26-7.23 (m, 4H), 7.19 (d, J = 8.0 Hz, 1H), 7.12 (d, J = 7.5 Hz, 1H), 7.03 (d, J = 8.0 Hz, 1H), 6.92 (dd, J = 8.5,2.0 Hz, 1H), 3.79 (s, 3H), 2.39 (s, 3H), 2.08 (s 3H). High-resolution mass spectrometry (ESI-TOF, m/z) analysis resulted in a calculated value of 351.1320 for C18H18N2O2F3 ([M + H]+); the measured value was 351.1311.

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[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 2, p. 524 - 527