ChemicalBook CAS DataBase List 113594-64-2

113594-64-2

Name	1-Piperazineacetic acid, 4-[(3,4,5-trimethoxyphenyl)methyl]-, 4-methoxyphenyl ester
CAS	113594-64-2
Molecular Formula	C23H30N2O6
Molecular Weight	430.49
MOL File	113594-64-2.mol

Chemical Properties

Melting point	94-97 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
Boiling point	553.2±50.0 °C(Predicted)
density	1.176±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (232.29 mM; Need ultrasonic)
form	Solid
pka	6.21±0.10(Predicted)
color	White to off-white

Hazard Information

Uses

Biological Activity

KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent[1][2]. KB-5492 (0.001-100 μM) free base inhibits specific [3H]DTG binding in a concentration-dependent manner[1].KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells[2]. KB-5492 (200 mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa[2].

in vivo

KB-5492 (200?mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa^[2].

Animal Model:	Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage^[2]
Dosage:	200?mg/kg
Administration:	Oral gavage
Result:	Reduced the lesion length as compared with the control. Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.

References

[1]. Harada Y, et, al. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur J Pharmacol. 1994 May 2; 256(3): 321-8.[2]. Morimoto Y, et, al. Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro. Jpn J Pharmacol. 1994 Jan; 64(1): 41-7.

Spectrum Detail

Supplier

Send Inquriy