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112809-51-5

Name Letrozole
CAS 112809-51-5
EINECS(EC#) 675-034-8
Molecular Formula C17H11N5
MDL Number MFCD00866241
Molecular Weight 285.3
MOL File 112809-51-5.mol

Chemical Properties

Appearance white to off-whitecrystalline powder
Features Letrozole(112809-51-5) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally-responsive breast cancer.
Melting point  181-183°C
Boiling point  563.5±60.0 °C(Predicted)
density  1.21±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: >50mg/mL
form  White powder
pka 1.52±0.11(Predicted)
color  white to off-white
Usage A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic
Merck  14,5450
InChIKey HPJKCIUCZWXJDR-UHFFFAOYSA-N
CAS DataBase Reference 112809-51-5(CAS DataBase Reference)
FDA-approved use Letrozole(112809-51-5) is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women. Side effects include signs and symptoms of hypoestrogenism. There is concern that long term use may lead to osteoporosis, which is why prescriptions of Letrozole are often accompanied by prescriptions of osteoporosis-fighting medications such as bisphosphonates.

Safety Data

Hazard Codes  Xi
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
WGK Germany  3
RTECS  DI4957000
HS Code  2933997500
Hazardous Substances Data 112809-51-5(Hazardous Substances Data)

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