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110-18-9

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Identification

Name
N,N,N',N'-Tetramethylethylenediamine
CAS
110-18-9
Synonyms
1,2-BIS(DIMETHYLAMINO)ETHANE
1,2-DI(DIMETHYLAMINO)ETHANE
1,4-DIAMINOBUTANE
BIS(DIMETHYLAMINO)ETHANE
N,N,N'N'-TETRAMETHYETHYLENEDIAMINE
NNN'N'-TETRAMETHYL-1,2-DIAMINOETHANE
NNN'N-TETRAMETHYL-1,2-DIAMINOETHANE
N,N,N',N'-TETRAMETHYLENEDIAMINE
N,N,N',N'-TETRAMETHYLETHYLENDIAMINE
N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE
N,N,N,N-TETRAMETHYL-ETHYLENEDIAMINE
N,N,',N-TETRAMETHYLETHYLENDIAMINE
TD
TEMED
TETRAMETHYLETHYLENEDIAMINE
TMEDA
(CH3)2NCH2CH2N(CH3)2
1,2-Diaminoethane, N,N,N',N'-tetramethyl-
1,2-Ethanediamine,N,N,N’,N’-tetramethyl-
2-Ethanediamine,N,N,N’,N’-tetramethyl-1
EINECS(EC#)
203-744-6
Molecular Formula
C6H16N2
MDL Number
MFCD00008335
Molecular Weight
116.2
MOL File
110-18-9.mol

Chemical Properties

Appearance
Colorless to slightly yellow liquid
Melting point 
−55 °C(lit.)

mp 
−55 °C(lit.)

Boiling point 
120-122 °C(lit.)

bp 
120-122 °C(lit.)

density 
0.775 g/mL at 20 °C(lit.)

vapor density 
4 (vs air)

vapor pressure 
21 hPa (20 °C)
refractive index 
n20/D 1.4179(lit.)

Fp 
50 °F

storage temp. 
Store at RT.
solubility 
H2O: 10 mg/mL at 20 °C, clear, colorless

form 
Liquid
pka
10.40, 8.26(at 25℃)
Specific Gravity
0.777 (20/4℃)
color 
Clear colorless to slightly yellow
Odor
Amine like
Stability:
Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, copper, mercury.
PH
8.0-8.5 (0.1g/l, H2O, 20℃)
explosive limit
1-9%(V)
Water Solubility 
miscible
Sensitive 
Hygroscopic
Detection Methods
GC,NMR
Merck 
9134
BRN 
1732991
InChIKey
DMQSHEKGGUOYJS-UHFFFAOYSA-N
CAS DataBase Reference
110-18-9(CAS DataBase Reference)
NIST Chemistry Reference
1,2-Ethanediamine, N,N,N',N'-tetramethyl-(110-18-9)
Storage Precautions
Air sensitive;Moisture sensitive
EPA Substance Registry System
110-18-9(EPA Substance)

Safety Data

Hazard Codes 
F,C,Xi
Risk Statements 
R11:Highly Flammable.
R20/22:Harmful by inhalation and if swallowed .
R34:Causes burns.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Statements 
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR 
UN 2372 3/PG 2

WGK Germany 
1

RTECS 
KV7175000


3-8-10-34
Autoignition Temperature
145 °C
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29212900
Safety Profile
Moderately toxic by ingestion. Mddly toxic by slun contact. A skin and severe eye irritant. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx. See also MINES.
Hazardous Substances Data
110-18-9(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description
A water-white colored liquid with a fishlike odor. Flash point 68°F. Less dense than water. Vapors heavier than air. Used to make other chemicals.
Reactivity Profile
1,2-DI-(DIMETHYLAMINO)ETHANE(110-18-9) neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Air & Water Reactions
Highly flammable. Slightly soluble in water. Sensitive to heat and may be sensitive to air .
Health Hazard
May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Chemical Properties
Colorless to slightly yellow liquid
Uses
anti-hyperlipidemic, plant growth stimulator, pathogen growth inhibitor, confers plant disease resistance
Uses
N,N,N',N'-Tetramethylethylenediamine is used as polymerization accelerator in gel electrophoresis, solvent and oxidizing reagent.
Uses
Polymerization accelerator in gel electrophoresis, solvent and oxidizing reagent.
Definition
ChEBI: An ethylenediamine derivative in which each nitrogen carries two methyl substituents. It is widely employed both as a ligand for metal ions and as a catalyst in organic polymerisation.
Purification Methods
Dry TMEDA partially with molecular sieves (Linde type 4A), then distil it in a vacuum from butyl lithium. This treatment removes all traces of primary and secondary amines and water. [Hay et al. J Chem Soc, Faraday Trans 1 68 1 1972.] Or dry it with KOH pellets, reflux for 2hours with one-sixth its weight of n-butyric anhydride (to remove primary and secondary amines) and fractionally distil it. Reflux it with fresh KOH, and distil it under nitrogen. [Cram & Wilson J Am Chem Soc 85 1245 1963.] It was also distilled from Na. Store it sealed under N2. The dipicrate has m 263o(dec). [Beilstein 4 H 250, 4 I 415, 4 II 690, 4 III 512, 4 IV 1172.]

Material Safety Data Sheet(MSDS)

msds information
TEMED(110-18-9).msds

Spectrum Detail

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