1085822-09-8

CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 μM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 μM, 15.25 μM, and 11.9 μM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy[1].

CK2: 0.5 μM (IC₅₀); CK2: 0.25 μM (Ki); ERK8: 0.5 μM (IC₅₀); PIM1: 8.65 μM (Ki); HIPK2: 15.25 μM (Ki); DYRK1A: 11.9 μM (Ki); Apoptosis

Store at -20°C

[1] Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65. DOI:10.1042/BJ20080309