The general procedure for the synthesis of (3-amino-2-fluorophenyl)methanol from 2-fluoro-3-nitrobenzyl alcohol was as follows: in the presence of a Pt/C catalyst, (3-nitro-2-fluorophenyl)methanol (2.1 g, 12.28 mmol) was dissolved in AcOEt solution and the reaction was carried out by reduction for 1 h at 30 Psi hydrogen pressure. After completion of the reaction, the catalyst was removed by filtration and the solvent was evaporated to give (3-amino-2-fluorophenyl)methanol (1.64 g, 95% yield) in yellow solid form. Its NMR spectrum (DMSO-d6) data were as follows: δ 4.34 (d, 2H), 4.74 (bs, 2H), 5.12 (t, 1H), 6.59 (dd, 1H), 6.77 (ddd, 1H), 6.91 (dd, 1H).
