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1034-01-1

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Identification

Name
Octyl gallate
CAS
1034-01-1
Synonyms
GALLIC ACID N-OCTYL ESTER
GALLIC ACID OCTYL ESTER
N-OCTYL GALLATE
OCTYL 3,4,5-TRIHYDROXYBENZOATE
OCTYL GALLATE
3,4,5-trihydroxy-benzoicacioctylester
n-octylesterof3,4,5-trihydroxybenzoicacid
oktylesterkyselinygallove
Gallic Acid Octyl Eester
Benzoic acid, 3,4,5-trihydroxy-, octyl ester
OCTYL GALLATE(OCTYL 3,4,5-TRIHYDROXYBENZOATE)
OCTYLGALLATE(RG)
n-Octyl gallate, 98+%
Progallin O
3,4,5-Trihydroxybenzoic acid octyl ester
Gallic acid octyl
Stabilizer GA-8
EINECS(EC#)
213-853-0
Molecular Formula
C15H22O5
MDL Number
MFCD00002197
Molecular Weight
282.33
MOL File
1034-01-1.mol

Chemical Properties

Melting point 
101-104 °C(lit.)

mp 
101-104 °C(lit.)

Boiling point 
262.5°C (estimate)
density 
1.0984 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
0-6°C
solubility 
soluble2.5%, clear, colorless (AcOH (MEOH))
BRN 
2132305
Contact allergens
Octyl gallate, a gallate ester (E 311), is an antioxidant added to food and cosmetics to prevent oxidation of unsaturated fatty acids. Cases were sparsely reported in food industry or from lipsticks. Patch tests are frequently irritant.
Uses
Used in treatment of alcohol dependence.
CAS DataBase Reference
1034-01-1(CAS DataBase Reference)
EPA Substance Registry System
1034-01-1(EPA Substance)

Hazard Information

Chemical Properties
White powder
Definition
ChEBI: A gallate ester obtained by condensation of the carboxy group of gallic acid with the hydroxy group of octanol.

Safety Data

Hazard Codes 
Xn
Risk Statements 
R22:Harmful if swallowed.
R43:May cause sensitization by skin contact.
Safety Statements 
S24:Avoid contact with skin .
S37:Wear suitable gloves .
WGK Germany 
1

RTECS 
LW8225000

TSCA 
Yes
HS Code 
29182900
Safety Profile
A poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes.

Material Safety Data Sheet(MSDS)

Questions And Answer

Description
Octyl gallate is the ester formed by 1-octanol and gallic acid. It can be used as an antioxidant and preservative to be supplemented to the food. It has been demonstrated to be an effective fungicide being capable of inhibiting the growth of S. cerevisiae and Z. bailii as it can inhibit the fluidity of the cell membrane through acting as a nonionic surface-active agent. It is also capable of killing both DNA and RNA viruses with a relatively moderate cytotoxicity. For example, it has the potential to treat influenza. Octyl gallate also has certain bactericidal activity, being capable of treating the infections associated with enterococci.
References
[1]Ken-Ichi, Fujita, and K. Isao. "Antifungal activity of octyl gallate. " International Journal of Food Microbiology 79.3(2002):1
[2]Gutiérrez-Fernández, J, et al. "Antimicrobial activity of binary combinations of natural and synthetic phenolic antioxidants against Enterococcus faecalis. " Journal of Dairy Science 96.8(2013):4912-20.93.
[3] Yamasaki, H, et al. "Antiviral effect of octyl gallate against influenza and other RNA viruses. " International Journal of Molecular Medicine 19.4(2007): 685-688.

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