103051-26-9

Name	B 746
CAS	103051-26-9
Molecular Formula	C26H20Cl2N4
Molecular Weight	459.37
MOL File	103051-26-9.mol

Synonyms

B 746 Clofazimine Impurity 3

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Chemical Properties

Boiling point	561.5±50.0 °C(Predicted)
density	1.30±0.1 g/cm3(Predicted)
pka	9.13±0.10(Predicted)

Hazard Information

Description

B 746 is an antibacterial agent primarily used in therapy for leprosy and Mycobacterium avium infections as well as against Mycobacterium tuberculosis, including those with multi-drug resistance.

Uses

B746 is a clofazimine analog with anti-Mycobacterium avium complex (MAC) activity and is less effective when used with clofazimine or streptomycin[1].

in vivo

B746 (p.o.; 10, 20, 30 mg/kg; single dose; first day and 2, 4 and 6 weeks) inhibits Mycobacterial growth in spleen of beige mice^[1].

Animal Model:	beige mice
Dosage:	10, 20, 30 mg/kg
Administration:	p.o.; 10, 20, 30 mg/kg; single dose; first day and 2, 4 and 6 week after infection
Result:	Reduced Colony Forming Units (CFU) counts of Mycobacteria in spleen of beige mice.

References

[1] Gangadharam PR, et al. In vitro, in vivo, and intracellular chemotherapeutic activity of B746, a clofazimine analogue against Mycobacterium avium complex. Tuber Lung Dis. 1992 Aug;73(4):192-9. DOI:10.1016/0962-8479(92)90085-x

Supplier

Jinan blalong chemical co. LTD

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QUALITY CONTROL SOLUTIONS LTD.

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TargetMol Chemicals Inc.

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