A number of 17-
aryl trinor and 16-
aryloxy tetranor prostaglandin F
2α derivatives have been approved for the treatment of glaucoma.
1,2,3 These “ring” prostaglandin (PG) analogs have improved efficacy over the PGs with an n-
alkyl lower side chain. Of these, the ones wherein the 13,14-
double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.
4 17-
trifluoromethylphenyl-
13,14-
dihydro trinor PGF
1α (17-
TFM-
PGF
1α) is a typical “ring” analog reminiscent of the trifluoromethyl-
phenoxy ring of Travoprost. The a chain of 17-
TFM-
PGF
1α is saturated, making this compound a formal member of the one-
series PGs. Recent work has shown that in the “ring” series of analogs, this modification has little impact on FP receptor binding.
5 As an ocular hypotensive agent, it is expected that 17-
TFM-
PGF
1α would act very much like the free acid of latanoprost.