Sappanone A is a homoisoflavonoid with diverse biological activities that has been isolated from the aerial parts of
C. pulcherrima, the heartwood of
C. sappan, and the stems of
H. campechianum.
1,2,3,4,5 In vitro, sappanone A inhibits 76.2, 59.2, 37.4, and 35.4% of FGFR1, KDR, c-Met, and c-Kit kinase activity, respectively, when used at a concentration of 10 μM.
1 It also inhibits influenza viral neuraminidase (NA) with IC
50 values of 0.7, 1.1, and 1 μM for H1N1, H3N2, and H9N2 influenza viral NAs, respectively.
2 Sappanone A has antibacterial activity against Gram-positive
B. subtilis,
B. sphaericus, and
S. aureus as well as Gram-negative
K. aerogenes and
C. violaceum.
3 It also inhibits the growth of
A. niger and
C. albicans fungi. Sapannone A inhibits LPS-induced inflammatory responses
in vitro and
in vivo, reducing nitric oxide (NO), interleukin-6 (IL-6), and prostaglandin E
2 (PGE
2; Item No.
14010) production in RAW264.7 cells as well as LPS-induced mortality in mice.
4 It also attenuates airway inflammation and mucus hypersecretion
via activation of the Nrf2 signaling pathway in a mouse model of ovalbumin-induced asthma.
5 
