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10102-43-9

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Identification

Name
NITRIC OXIDE
CAS
10102-43-9
Synonyms
NITRIC OXIDE
NITROGEN MONOXIDE
Amidogen, oxo-
bioxyded’azote
bioxyded’azote(french)
mononitrogenmonoxide
nitric
nitricoxide0
nitricoxidetrimer
Nitrogenoxide(Nitricoxide)
nitrogenoxide(no)
Nitrosyl radical
nitrosylradical
NO
oxo-amidoge
oxydenitrique
oxydenitrique(french)
rcrawastenumberp076
stickmonoxyd
Stickstoff(II)-oxid
EINECS(EC#)
233-271-0
Molecular Formula
NO *
MDL Number
MFCD00011525
Molecular Weight
30.01
MOL File
10102-43-9.mol

Chemical Properties

Appearance
colourless gas turning brown upon exposure to air
Appearance
Nitric oxide is a colorless gas with a sharp, sweet odor; brown at high concentration in air. Shipped as a nonliquefied compressed gas.
Melting point 
−163.6 °C(lit.)

mp 
−163.6 °C(lit.)

Boiling point 
−151.7 °C(lit.)

bp 
−151.7 °C(lit.)

density 
d-150.2 (liq) 1.27; Relative d (gas) 1.036 (air = 1); Absolute d (gas) 1.227 (air = 1)
vapor density 
1.05 (vs air)

refractive index 
nD25 1.0002697
solubility 
At 20 °C and at a pressure of 101 kPa, 1 volume dissolves in about 21 volumes of water.
form 
colorless gas
Stability:
Spontaneously reacts with oxygen in air to yield brown nitrogen dioxide. Reacts violently or explosively with ammonia and many organic materials.
Water Solubility 
slightly soluble H2O [HAW93]
Merck 
13,6611
CAS DataBase Reference
10102-43-9(CAS DataBase Reference)

Questions And Answer

Uses
Nitric oxide is an important intermediate in the production of nitric acid. Fluorine, chlorine, and bromine react with nitric oxide to form the corresponding nitrosyl halide. [t is also used in making mixtures for calibration standards for stationary and mobile exhaust emission measurements.

Hazard Information

Chemical Properties
Nitric oxide is a colorless gas with a sharp, sweet odor; brown at high concentration in air. Shipped as a nonliquefied compressed gas.
Chemical Properties
Nitric oxide,NO, also known as nitrogen oxide and nitrogen monoxide, is a colorless gas that will react with oxygen at room temperature to form nitrogen dioxide, N202, a reddish-brown gas.It is soluble in water and alcohol and is used primarily to form other compounds.
Definition
ChEBI: Nitric Oxide is a nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.
General Description
A colorless gas. Noncombustible but accelerates the burning of combustible material. Vapors heavier than air. Very toxic by inhalation and skin absorption. Heating the containers may cause them to rupture violently and rocket.
Reactivity Profile
NITRIC OXIDE can serve as both an oxidizing agent and as a reducing agent. Sustains the combustion of powdered aluminum [Mellor 5:209-212. 1946-47]. Enflames or explodes when mixed with vapors of carbon disulfide [Mellor 8, Supp. 2:232. 1967]. Reacts vigorously with sodium monoxide above 100°C [Mellor 2, Supp. 2:629. 1961]. Reacts on contact with oxygen at room temperature to form brown gaseous nitrogen dioxide. Reacts with alkalis to form nitrates and nitrites [Merck 11th ed. 1989]. The liquid is very sensitive to detonation in the presence of water.
Air & Water Reactions
Combines very rapidly with oxygen in the air to form nitrogen dioxide. Nitrogen dioxide reacts with water to form nitric acid and NITRIC OXIDE(10102-43-9), reacts with alkalis to form nitrates and nitrites [Merck 11th ed. 1989].
Hazard
Supports combustion. Toxic by inhalation, strong irritant to skin and mucous membranes. Hypoxia/cyanosis, nitrosyl-hemoglobin formation, and upper respiratory tract irritant.
Health Hazard
Can cause death or permanent injury after a very short exposure to small quantities. Irritant of eyes, nose, throat; can cause unconsciousness. Nitric oxide forms acids in the respiratory system which are irritating and cause congestion in the lungs. Concentrations of 60-150 ppm cause immediate irritation of the nose and throat with coughing and burning in the throat and chest. 6-24 hours after exposure, labored breathing and unconsciousness may result. Concentrations of 100-150 ppm are dangerous for short exposure of 30-60 minutes. Concentrations of 200-700 ppm may be fatal after very short exposure.
Potential Exposure
Nitric oxide is used in the manufacture of nitric acid; it is also used in the bleaching of rayon; it is a raw material for nitrosyl halide preparation.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Effects may be delayed; keep victim under observation. Medical observation is recommended for 24 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.
Shipping
UN1660/124 Nitric oxide, compressed, Hazard Class: 2.3; Labels: 2.3-Poisonous gas, 5.1-Oxidizer, 8-Corrosive material, Inhalation Hazard Zone A. Cylinders must be transported in a secure upright position, in a wellventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner.
Incompatibilities
A strong oxidizer but may also act as a reducing agent. Explosive reaction with nitrogen trichloride, ozone, carbon disulfide; pentacarbonyl iron; chlorine monoxide. Incompatible with halogens, combustibles, metals, oil, alcohols, chlorinated hydrocarbons (e.g., trichloroethylene), reducing agents (such as NH3), oxygen, fluorine, metals. Reacts with water to form nitric acid. Rapidly converted in air to nitrogen dioxide. Combines very rapidly with oxygen in the air to form nitrogen dioxide. Nitrogen dioxide reacts with water to form nitric acid and nitric oxide, reacts with alkalis to form nitrates and nitrites.
Waste Disposal
Return refillable compressed gas cylinders to supplier. Incineration with added hydrocarbon fuel, controlled so as to produce elemental nitrogen, CO2, and water. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/ mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Purification Methods
Bubble the gas through 10M NaOH which removes NO2. It can also be freed from NO2 by passage through a column of Ascarite followed by a column of silica gel held at -197oK. The gas is dried with solid NaOH pellets or by passing through silica gel cooled at -78o, followed by fractional distillation from a liquid N2 trap. This purification does not eliminate nitrous oxide. Other gas scrubbers sometimes used include one containing conc H2SO4 and another containing mercury. It is freed from traces of N2 by the freeze and thaw method. [Blanchard Inorg Synth II 126 1946, Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I pp 485-487 1963.] TOXIC.

Safety Data

Hazard Codes 
O,T
Risk Statements 
R8:Contact with combustible material may cause fire.
R23:Toxic by inhalation.
R34:Causes burns.
R44:Risk of explosion if heated under confinement.
Safety Statements 
S17:Keep away from combustible material .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR 
UN 1660 2.3

WGK Germany 
1

RTECS 
QX0525000

HazardClass 
2.3
Safety Profile
A poison gas. A severe eye, skin, and mucous membrane irritant. A systemic irritant by inhalation. Mutation data reported. Exposure may occur whenever nitric acid acts upon organic material, such as wood, sawdust, and refuse; it occurs when nitric acid is heated, and when organic nitro compounds are burned, for example, celluloid, cellulose nitrate (guncotton), and dynamite. The action of nitric acid upon metals, as in metal etchng and pickling, also liberates the fumes. In hgh-temperature weldmg, as with the oxyacetylene or electric torch, the nitrogen and oxygen of the air unite to form oxides of nitrogen. Automobile exhaust and power plant emissions are also sources of NOx. Exposure occurs in many manufacturing nitric and nitrous acids. This is the action that takes place deep in the respiratory system. The acids formed are irritating and can cause congestion in the throat and bronchi and edema of the lungs. The acids are neutralized by the alkalies present in the tissues, with the formation of nitrates and nitrites. The latter may cause some arterial ddation, fall in blood pressure, headache, and dizziness, and there may be some formation of methemoglobin. However, the nitrite effect is of secondary importance. Because of their relatively low solubllity in water, the nitrogen oxides are initially only slightly irritating to the mucous membranes of the upper respiratory tract. Their warning power is therefore low, and dangerous amounts of the fumes may be breathed before the worker notices any real discomfort. Higher concentrations (60-150 ppm) cause immediate irritation of the nose and throat, with coughing and burning in the throat and chest. These symptoms often clear upon breathing fresh air, and the worker may feel well for several hours. Some 6-24 hours after exposure, a sensation of tightness and burning in the chest develops, followed by shortness of breath, sleeplessness, and restlessness. Dyspnea and air hunger may increase rapidly with development of cyanosis and loss of consciousness followed by death. In cases that recover from the pulmonary edema, there is usually no permanent disabiltty, but pneumonia may develop later. Concentrations of 100-150 ppm are dangerous for short exposures of 30-60 minutes. Concentrations of 200-700 ppm may be fatal after even very short exposures. Continued exposure to low concentrations of the fumes, insufficient to cause pulmonary edema, is said to result in chronic irritation of the respiratory tract, with cough, headache, loss of appetite, dyspepsia, corrosion of the teeth, and gradual loss of strength. Exposure to NOx is always potentially serious, and persons so exposed should be hours. An oxidizer. The liquid is a sensitive explosive. Explosive reaction with carbon disulfide (when ignited), methanol (when ignited), pentacarbonyl iron (at 50℃), phosphine + oxygen, sodium diphenylketyl, dichlorine oxide, fluorine, nitrogen trichloride, ozone, perchloryl fluoride (at 100-300°C), vinyl chloride. Reacts to form explosive products with dienes (e.g., 1,3- butadiene, cyclopentadiene, propadiene). Can react violently with acetic anhydride, Al, amorphous boron, BaO, BCl3, CsHC2, calcium, carbon + potassium hydrogen tartrate, charcoal, Cl0, pyrophoric chromium, 1,2-dichloroethane, dichloroethylene, ethylene, fuels, hydrocarbons, hydrogen + oxygen, NasO, uns-dimethyl hydrazine, NH3, CHCl3, Fe, Mg, Mn, CH2Cl2, olefins, phosphorus, PNH2, PH3, potassium, potassium sulfide, propylene, rubidum acetylide, Na, S, tungsten carbide, trichloroethylene, 1,1,1- trichloroethane, uns-tetrachloroethane, uranium, uranium dicarbide. Wdl react with water or steam to produce heat and corrosive fumes; can react vigorously with reducing materials. processes when nitric acid is made or used. Oxides of nitrogen have been implicated as a cause of acid rain. The oxides of nitrogen are somewhat soluble in water, reacting with it to form

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

Questions and Answers (Q&A)

Uses
Industry
Application
Role/benefit
Chemical manufacture
Manufacture of nitric acid
Intermediate
Manufacture of hydroxylamine
Intermediate
Medcine
Treatment of primary pulmonary hypertension
Active ingredient/helps to promote capillary and pulmonary dilation
Treatment of respiratory failure in premature babies
Active ingredient/can relax smooth muscle to widen (dilate) blood vessels
Treatment of impotence or erectile dysfunction
Active ingredient/enhances nitric oxide’s relaxant effects on smooth muscle cells in the corpus cavernosa
Chemical analysis
Detecting surface radicals on polymers
Radicals quenching agent
Analysis for nitric acid or its salts
Analytical agent
Others
Narcotics and preservatives
Effective component
Rayon production
Decolorizer
Propylene and dimethyl ether preservation
Stabilizing agent
Semiconductor manufacturing
Oxidation and chemical vapor deposition gas
 

References
1.https://en.wikipedia.org/wiki/Nitric_oxide 2.https://www.drugs.com/mtm/nitric-oxide-inhalation-gas.html 3.https://www.britannica.com/science/nitric-oxide 4.http://pediatrics.aappublications.org/content/106/2/344 5.http://www.mensfitness.com/nutrition/supplements/supplement-guide-nitric-oxide 6.https://www.chemicalbook.com/ProductChemicalPropertiesCB5433122.htm

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