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10102-17-7

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Identification

Name
Sodium thiosulfate pentahydrate
CAS
10102-17-7
Synonyms
ANTICHLOR
HYPO
SODIUM HYPOSULFATE, PENTAHYDRATE
SODIUM HYPOSULFITE
SODIUM HYPOSULFITE, PENTAHYDRATE
sodium subsulfite
SODIUM THIOCYANATE
SODIUM THIOSULFATE
SODIUM THIOSULFATE, 5-HYDRATE
SODIUM THIOSULFATE PENTAHYDRATE
SODIUM THIOSULPHATE
SODIUM THIOSULPHATE 5H2O
SODIUM THIOSULPHATE 5-HYDRATE
SODIUM THIOSULPHATE PENTAHYDRATE
ametox
nsc-45624
Sodiumthiosulfate,pentahydrat
Sulfothiorine
thiosulfuricacid(h2s2o3),disodiumsalt,pentahydrate
Thiosulfuricacid(H2S2O3)disodiumsalt,pentahydrate
EINECS(EC#)
231-867-5
Molecular Formula
H10Na2O8S2
MDL Number
MFCD00149186
Molecular Weight
248.18
MOL File
10102-17-7.mol

Chemical Properties

Appearance
translucent crystals or white powder
Melting point 
48.5 °C
mp 
48.5 °C
Boiling point 
100 C
bp 
100 C
density 
1.01 g/mL at 25 °C

storage temp. 
Store at RT.
solubility 
H2O: 1 M at 20 °C, clear, colorless

form 
Solid
color 
White tranparent
Specific Gravity
1.729
PH Range
6 - 8.5
PH
6.0-7.5 (100g/l, H2O, 20℃)
Stability:
Stable. Incompatible with strong acids, iodine, mercury.
Odor
Odorless
Water Solubility 
680 g/L (20 ºC)
Merck 
14,8694
InChIKey
AKHNMLFCWUSKQB-UHFFFAOYSA-L
CAS DataBase Reference
10102-17-7(CAS DataBase Reference)
EPA Substance Registry System
10102-17-7(EPA Substance)

Safety Data

Hazard Codes 
Xi
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
WGK Germany 
1

RTECS 
WE6660000


10
TSCA 
Yes
HS Code 
28323000
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

Hazard Information

Chemical Properties
Sodium thiosulfate occurs as odorless and colorless crystals, a crystalline powder or granules. It is efflorescent in dry air and deliquescent in moist air.
Chemical Properties
translucent crystals or white powder
Uses
Titrimetry.
Production Methods
On an industrial scale, sodium thiosulfate is produced chiefly from liquid waste products of sodium sulfide or sulfur dye manufacture. Small-scale synthesis is done by boiling an aqueous solution of sodium sulfite with sulfur.
Brand name
Sulfactol (Sterling Winthrop).
Pharmaceutical Applications
Sodium thiosulfate is used as an antioxidant in pharmaceuticals (ophthalmic, intravenous, and oral preparations). It has also been used for its antifungal properties and as a reagent in analytical chemistry.
Safety
Sodium thiosulfate is used in ophthalmic, intravenous, and oral pharmaceutical preparations. Apart from osmotic disturbances, sodium thiosulfate is relatively nontoxic. It is moderately toxic by the subcutaneous route and mildly irritating to respiratory tract and skin. Large oral doses have a cathartic action.
LD50 (IP, mouse) 5.6 g/kg
LD50 (IV, mouse) 2.4 g/kg
storage
Sodium thiosulfate decomposes on heating. The bulk powder should be stored in a cool place, and the container should be kept tightly closed in a dry and well-ventilated place. It should not be stored near acids.
Purification Methods
Crystallise it from EtOH/H2O solutions or from water (0.3mL/g) below 60o by cooling to 0o, and dry it at 35o over P2O5 under vacuum. [Foerster & Mommsen Chem Ber 57 258 1924.] This salt is used as a secondary standard in volumetric analysis [Kilpatrick J Am Chem Soc 45 2132 1923], and is used as “Hypo” in photography [Hargreaves & Dunningham J Soc Chem Ind 42 147T 1923.]
Incompatibilities
Sodium thiosulfate is incompatible with iodine, with acids, and with lead, mercury, and silver salts. It may reduce the activity of some preservatives, including bronopol, phenylmercuric salts, and thimerosal.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (IV solutions; ophthalmic solutions and suspensions; oral capsules, solutions, and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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