Hazard Information
Definition
ChEBI:Amoscanate is an isothiocyanate that is phenyl isothiocyanate in which the hydrogen at the para- position has been replaced by a 4-nitroanilinyl group. It has a role as a schistosomicide drug. It is a C-nitro compound, an isothiocyanate and a secondary amino compound. It is functionally related to a diphenylamine.
Biological Activity
Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1].
Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain[1].Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum[1].Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma[1].Amoscanate elicits massive ultrastructural damage in ependymal cells[1].
References
[1]. Johanson C, et al. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol. 2011;39(1):186-212.
Supplier
Shanghai JiYi Biotechnology Co. Ltd.
Telephone 13621943973
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16460/0.htm
Shanghai Chaolan Chemical Technology Center
TelephoneQQ:65489617 15618227136
Websitehttps://www.superlan-chem.com
Amadis Chemical Company Limited
Telephone571-89925085
Websitehttp://www.amadischem.com
Medi-tech Bioscientific Co., Ltd.
Telephone0519-83246372 13585352506
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19938/0.htm
Nanjing KaiMubo Pharmaceutical Co., Ltd.
Telephone025-66162170
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19958/0.htm
DC Chemicals
Telephone021-58447131 13564518121
Websitehttps://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm
Beijing Jin Ming Biotechnology Co., Ltd.
Telephone010-60605840 15801484223;
Websitehttp://www.jm-bio.com/
InvivoChem
Telephone 13549236410
Websitehttps://www.invivochem.cn/
ATK CHEMICAL COMPANY LIMITED
Telephone+undefined-21-51877795
Websitehttp://www.atkchemical.com
1of2
PROMPT×
PROMPT
The What'sApp is temporarily not supported in mainland China
The What'sApp is temporarily not supported in mainland China
Cancel
Determine