1005784-60-0

Name	Benzamide, 4-(2-hydroxy-1,1-dimethylethyl)-N-[6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl]-
CAS	1005784-60-0
Molecular Formula	C21H21N5O2
Molecular Weight	375.42
MOL File	1005784-60-0.mol

Synonyms

CLK1/2IN3 CLK1/2-IN-3 CLK1/2 IN 3 CLK1/2 inhibitor 3 CLK1/2-inhibitor-3 Benzamide, 4-(2-hydroxy-1,1-dimethylethyl)-N-[6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl]-

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Chemical Properties

density	1.32±0.1 g/cm3(Predicted)
pka	4.84±0.46(Predicted)

Hazard Information

Description

CLK1/2-IN-3 is a selective CLK1 and CLK2 inhibitor.

Uses

LK1/2-IN-3 (compound 3) is a potent and selective CLK1 and CLK2 inhibitor with IC50 values of 1.1, 2.1, 130, 260, 260 nM for CLK1, CLK2, SRPK1, SRPK2, SRPK3, respectively. CLK1/2-IN-3 shows anti-proliferative activity. CLK1/2-IN-3 reduces the levels of endogenous phosphorylated SR proteins and increases the expression of S6K mRNAs[1].

IC 50

CLK1: 1.1 nM (IC₅₀); CLK2: 2.1 nM (IC₅₀); SRPK1: 130 nM (IC₅₀); SRPK2: 260 nM (IC₅₀); SRPK3: 260 nM (IC₅₀)

References

[1] Araki S, et al. Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing. PLoS One. 2015;10(1):e0116929. Published 2015 Jan 12. DOI:10.1371/journal.pone.0116929

Spectrum Detail

Benzamide, 4-(2-hydroxy-1,1-dimethylethyl)-N-[6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl]-(1005784-60-0)¹HNMR

Supplier

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Sangon Biotech (Shanghai) Co.,Ltd.

Telephone400-821-026

Websitehttp://www.sangon.com

Shanghai Amole Biotechnology Co., Ltd.

Telephone18017925202 18916960931

Websitehttps://www.amole.com.cn/

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