General Description
Solid.
Reactivity Profile
Incompatible with sodium hydroxide. [EPA, 1998]. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.
Air & Water Reactions
May react slowly with water.
Health Hazard
Poisonous if swallowed or dust is inhaled.
Potential Exposure
A chloronitrobenzene compound, used
in organic synthesis.
Fire Hazard
Incompatible with sodium hydroxide.
First aid
Move victim to fresh air. Call 911 or emergency
medical service. Give artificial respiration if victim is not
breathing. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respiration
with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult. Remove and
isolate contaminated clothing and shoes. In case of contact
with substance, immediately flush skin or eyes with running
water for at least 20 minutes. For minor skin contact,
avoid spreading material on unaffected skin. Keep victim
warm and quiet. Effects of exposure (inhalation, ingestion
or skin contact) to substance may be delayed. Ensure that
medical personnel are aware of the material(s) involved
and take precautions to protect themselves. Medical observation
is recommended for 24 to 48 hours after breathing
overexposure, as pulmonary edema may be delayed. As
first aid for pulmonary edema, a doctor or authorized paramedic
may consider administering a drug or other inhalation
therapy.
Shipping
UN3261 Corrosive solid, acidic, organic, n.o.s.,
Hazard class: 8; Labels: 8—Corrosive material, Technical
Name Required. UN1578 Chloronitrobenzenes, solid or liquid,
Hazard Class: 6.1; Labels: 6.1—Poisonous materials.
Incompatibilities
Can react with sulfuric acid. Keep
away from oxidizers, amines, bases: sodium hydroxide, and
potassium hydroxide; may cause fire and explosions.
Incompatible with strong oxidizing and reducing agents
such as hydrides, certain amines, nitrides, azo/diazo compounds,
alkali metals (potassium), and epoxides. Corrodes
steel, some plastics and human tissue.
Description
Benzene, 1-(chloromethyl)-4-nitro- is a crystalline solid. Molecular weight= 171.58; Freezing/Meltingpoint =71℃. Slightly soluble in water; slow reaction.
Chemical Properties
Benzene, 1-(chloromethyl)-4-nitro-, is a crystalline
solid.
Chemical Properties
white to light yellow crystal powde
Uses
4-Nitrobenzyl chloride was used to prepare unsymmetrically N,N′-bis(substituted) 4,13-diaza-18-crown-6-ether derivatives.
Definition
ChEBI: A C-nitro compound that is nitrobenzene in which the hydrogen at position 4 is replaced by a chloromethyl group.
Production Methods
Chlorination of 4-nitrotoluene at 190 ℃ without catalyst gives 4-Nitrobenzyl chloride. The alternative process of nitration of benzylchloride coproduces 2-nitrobenzyl chloride and requires a difficult separation stage.
storage
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Store in a refrigerator or in acool, dry place and protect from prolonged exposure tomoisture.
Purification Methods
Crystallise the chloride from CCl4, dry diethyl ether, or n-heptane, and dry it under vacuum. IRRITANT.[Beilstein 5 IV 856.]
