General Description
Yellow solid with a mild odor. Sinks in water.
Reactivity Profile
P-NITROANILINE may react vigorously with sulfuric acid above 392° F. P-NITROANILINE, [SOLID] may also react with sodium hydroxide at 266° F. Under pressure, P-NITROANILINE, [SOLID] may produce an explosive compound. P-NITROANILINE, [SOLID] is incompatible with strong oxidizers and strong reducing agents. P-NITROANILINE, [SOLID] is capable of explosive decomposition with strong initiators. P-NITROANILINE, [SOLID] will attack some forms of plastics, rubber and coatings.
Air & Water Reactions
P-NITROANILINE, [SOLID] may be sensitive to prolonged exposure to air and light. Insoluble in water. This chemical is sensitive to moisture.
Hazard
Explosion risk. Toxic when absorbed by
skin. Methemoglobinemia, liver damage and eye
irritant. Questionable carcinogen.
Health Hazard
Inhalation or ingestion causes headache, drowsiness, shortness of breath, nausea, methemoglobinemia, and unconsciousness; fingernails, lips, and ears become bluish; prolonged and excessive exposures may also cause liver damage. Contact with eyes causes irritation and possible corneal damage. Contact with skin causes irritation; continued exposure may cause same symptoms as inhalation or ingestion.
Potential Exposure
p-Nitroaniline is used as an intermediate
in the manufacture of dyes; antioxidants, pharmaceuticals,
and pesticides.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids.
Seek medical attention immediately. If this chemical contacts
the skin, remove contaminated clothing and wash
immediately with soap and water. Seek medical attention
immediately. If this chemical has been inhaled, remove from
exposure, begin rescue breathing (using universal precautions,
including resuscitation mask) if breathing has stopped
and CPR if heart action has stopped. Transfer promptly to a
medical facility. When this chemical has been swallowed,
get medical attention. Give large quantities of water and
induce vomiting. Do not make an unconscious person vomit.
Shipping
UN1661 Nitroanilines (m-, o-, p-), Hazard Class:
6.1; Labels: 6.1-Poisonous materials.
Incompatibilities
A combustible liquid. A strong oxidizer.
Incompatible with strong acids; sulfur, combustibles, organics,
and other easily oxidizable materials. Will accelerate
the burning of combustible materials. If large quantities are
involved in a fire or the combustible material is finely
divided, an explosion may result. Prolonged exposure to
fire or heat may result in an explosion.
Chemical Properties
p-Nitroaniline consists of yellow crystals with a
pungent, faint ammonia-like odor.
Chemical Properties
Yellow fine crystals
Waste Disposal
Incineration (982℃, 2.0 seconds
minimum) with scrubbing for nitrogen oxides abatement.
Consult with environmental regulatory agencies for
guidance on acceptable disposal practices. Generators of
waste containing this contaminant (≥100 kg/mo) must conform
with EPA regulations governing storage, transportation,
treatment, and waste disposal.
Physical properties
Bright yellow crystalline powder or flakes with a faint, ammonia-like, slightly pungent odor.
Combustible.
Uses
4-Nitroaniline is used in the synthesis of photorefractive polymers, as novel chromophores in analytical study. As well, due to the absorption spectrum associated with 4-Nitroaniline, it is used to de
termine catechol derivatives in syntheses.
Uses
Dyestuff intermediate.
Uses
Product of chromogenic reactions.
Definition
ChEBI: A nitroaniline carrying a nitro group at position 4.
Flammability and Explosibility
Nonflammable
Carcinogenicity
p-Nitroaniline has been tested in
several strains of S. typhimurium. It was mutagenic in strain
TA98 but not in strains TA97, TA100, TA1535, and TA1537,
with and without S9. It caused gene mutation in mouse
lymphoma cells and chromosomal aberrations in CHO
cells in the presence of S9.
Environmental Fate
Biological. A Pseudomonas sp. strain P6, isolated from a Matapeake silt loam, was grown using
a yeast extract. After 8 d, 4-nitroaniline degraded completely to carbon dioxide (Zeyer and
Kearney, 1983). In activated sludge inoculum, following a 20-d adaptation period, no degradation
was observed (Pitter, 1976).
Chemical/Physical: Spacek et al. (1995) investigated the photodegradation of 4-nitroaniline
using titanium dioxide-UV light and Fenton’s reagent (hydrogen peroxide:substance – 10:1; Fe2+
2.5 x 10-4 mol/L). Both experiments were conducted at 25 °C. The decomposition rate of 4-nitroaniline
was very high by the photo-Fenton reaction in comparison to titanium dioxide-UV light (λ
= 365 nm). Decomposition products identified in both reactions were nitrobenzene, pbenzoquinone,
hydroquinone, oxalic acid, and resorcinol. Oxalic acid, hydroquinone, and pbenzoquinone
were identified as intermediate products using HPLC.
At influent concentrations of 10, 1.0, 0.1, and 0.01 mg/L, the GAC adsorption capacities were 250,
140, 74, and 40 mg/g, respectively (Dobbs and Cohen, 1980).
Purification Methods
It also crystallises from acetone. It is freed from o-and m-isomers by zone melting and sublimation. [Beilstein 12 IV 1613.]
