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What is Dimethylamine hydrochloride?

Feb 20，2020

Dimethylamine hydrochloride Formula (CH3)2NH·HCl Molecular Weight 81.54 Properties Related Categories, Amine Salts, Building Blocks, Chemical Reagents, Chemical Synthesis, Development Quantities for Research,More... Assay 99% mp 170-173℃(lit.) solubility H2O: very soluble alcohol: soluble diethyl ether: soluble Specification Appearcance White Crystal Content ≥99.0% Ignition Residue ≤0.05% Drying Loss ≤2.0% Insoluble in Trichloromethane ≤0.2 PH Value 3-5 Melting point 168℃- 174℃ Solubility in water 50mg/ml H2O Moisture <1 % Heavy metals (as Pb) <50 ppm Insoluble matter in H2O <0.005 % Fe < 50 ppm SO4 < 50 ppm Description Packaging 25 kg in drum. Dimethylamine hydrochloride has been used in the preparation of hexamethylmelamine-methyl-14C. It has also been used to prepare the standard solution of methylamine (MA), dimethylamine (DMA), trimethylamine (TMA), and trimethylamine-N-oxide (TMAO) while determing methylamines and trimethylamine-N-oxide in particulate matter. Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde. Notes Hygroscopic. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agent.

Fig 1. Chemical structure formula and three-dimensional structure of Dimethylamine hydrochloride

Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, tramadol and amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde[1,2].

Dimethylamine hydrochloride has been used in the preparation of hexamethylmelamine-methyl-14C. It has also been used to prepare the standard solution of methylamine (MA), dimethylamine (DMA), trimethylamine (TMA), and trimethylamine-N-oxide (TMAO) while determing methylamines and trimethylamine-N-oxide in particulate matter.

Dimethylamine hydrochloride is derived from the salt formation of dimethylamine and hydrochloric acid. Hydrochloric acid was slowly dropped into dimethylamine. The amount of 30% hydrochloric acid was about 1.1 times that of 40% dimethylamine. The dropping rate was limited to a temperature not exceeding 15℃and pH = 7-8. After completion of the reaction, activated carbon was added to decolorize and filtered. The filtrate was adjusted to pH = 3-4 with hydrochloric acid, and the water was distilled under reduced pressure to obtain dimethylamine hydrochloride.Dimethylamine hydrochloride is a raw material for organic synthesis. It is also used as a catalyst and magnesium reagent for acetylation analysis.

References

[1]Lan, J. S.; Pan, L. F.; Xie, S. S.; Wang, X. B.; Kong, L. Y. Synthesis and evaluation of 6-methylcoumarin derivatives as potent and selective monoamine oxidase B inhibitors. Med. Chem. Commun. 2015, 6 (4), 592-600.

[2]Nortcliffe, A.; Moody, C. J. Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry. Bioorg Med Chem 2015, 23 (11), 2730-2735.

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