Uses of Belinostat
Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with traditional front-line therapies for the treatment of PTCL. Intravenous administration of the agent is available as Beleodaq as monotherapy and the dosing regimen involves a 21-day cycle. It was US-approved in July 2014 as a therapeutic agent for relapsed or refractory peripheral T-cell lymphoma.
Belinostat is used to treat a certain type of cancer: peripheral T-cell lymphoma (PTCL). Belinostat works by slowing or stopping the growth of cancer cells.
How to use Belinostat Solution, Reconstituted (Recon Soln)
Read the Patient Information Leaflet if available from your pharmacist before you start using belinostat and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
This medication is given by a health care professional in a clinic or hospital. It is injected into a vein as directed by your doctor, usually once a day on days 1 through 5 of a 21-day treatment cycle. The injection is given slowly, usually over 30 minutes. Tell your doctor or nurse right away if you notice redness, pain, or swelling during your injection. If you have side effects during the injection, your infusion may be given over a longer time, changed, or temporarily stopped.The dosage is based on your medical condition, body size, laboratory test results, and response to treatment.
Belinostat Side Effects
Important things to remember about the side effects of belinostat: Most people will not experience all of the belinostat side effects listed. Belinostat side effects are often predictable in terms of their onset, duration, and severity. Belinostat side effects will improve after therapy is complete. Belinostat side effects may be quite manageable. There are many options to minimize or prevent the side effects of belinostat.