The property and application of dimethicone

The property of dimethicone

Dimethicone is a fluid mixture of fully methylated linear siloxane polymers end-blocked with trimethylsiloxy units. Methicone is a linear monomethyl polysiloxane. Dimethicone are safe as used in cosmetic formulations, vulcanization [1].

Dimethicone can be used for vulcanization

The value of organosulfur compounds lies in their rich and diverse chemical properties, especially in the biological field. The product obtained by connecting organic sulfide and dimethicone in series can vulcanize various aromatic amides and esters. This method is easy to handle and has higher yield and efficiency.

The satety of dimethicone pediculocide in school-age children

Head lice most commonly affect children, ages 3 to 11. Concerns exist about the safety and efficacy of pesticide-based treatments. Published studies suggest dimethicone is a potentially safe and effective non-toxic treatment, but have not evaluated 100 % dimethicone in a pediatric population. The objectives were to evaluate the efficacy and safety of 100 % dimethicone for the treatment of head lice in children, monitored by school nurses.100 % dimethicone was found to be a safe and highly effective treatment for pediatric head lice. Because dimethicone avoids pesticide exposure and resistance issues, dimethicone should be considered as a first-line treatment for head lice [2].

The role of simethicone in the decrease of gastric potential difference

The gastric potential difference (PD) was measured in ten healthy volunteers after sodium taurocholate intake. This bile salt was given after treatment with dimethicone or placebo in a cross-over design study. With dimethicone the fall in PD was lower (16.1 vs. 24.8 mV,) and shorter (32.5 vs. 51.0 min) than with the placebo. Our result suggests that the silicone can prevent the formation of the gastric lesions induced by bile salts [3].

The Effect of Dimethicone on Clinical Signs and Skin Barrier Function

Based on human studies topical moisturizer applications are best used as adjunctive therapy. In people with AD (atopic dermatitis), it has been shown that routine use of a topical emollient can delay the need for topical glucocorticoid therapy [4]. Evidence suggests that the barrier creams are successful not only for the prevention of contact and irritant dermatitis but also in delaying the relapse of AD. Thus, in hindsight, it might have been better to design a study to test the ability of dimethicone to help as an adjunctive therapy to increase time to relapse in animals that were in remission rather than to test its ability to control clinical signs without any additional medication. As skin barrier repair is an area of growing interest, it is important to consider the investigation of treatment options that can be useful for dogs with AD. Although the results of this pilot study did not show evidence of clinical benefit for the topical use of dimethicone, it is important to encourage alternative and innovative therapy to treat AD. Larger studies including more patients and for a longer period of time are desirable to better assess the long-term impact of skin barrier repair treatments and their benefit as adjunctive therapies for canine AD.

The benefits of filling echography probes with water mixed with dimethicone

This study was designed to show the benefits of filling echography probes with water mixed with dimethicone to preclude artifacts caused by bubbles. METHODS: One hundred consecutive healthy volunteers (42 males; mean age, 46 years; range, 17–72 years) were blindly randomized to undergo rectal ultrasonography using conventional degassed water or degassed aqueous solution made of 40 ml of water and 10 ml of dimethicone emulsion (1 ml/100 mg). All examinations performed by the same surgeon—unaware of nature of filler liquid—for ten minutes, and number of rectal ultrasonographies with artifacts attributable to air bubbles was recorded. RESULTS: Endoluminal ultrasonography performed with conventional degassed water presented artifacts attributed to presence of air bubbles in 30 of 50 examinations (60 percent). When degassed aqueous solution was used, only 5 of 50 examinations showed artifacts caused by presence of air bubbles (10 percent). This difference was statistically significant (P < 0.0005). The use of conventional fluid was associated with artifacts secondary to the presence of air bubbles, adjusted odds ratio 13.5 (95 percent confidence interval, 4.56–39.88). During this experience, the solution did not damage ultrasound scanner. CONCLUSIONS: We found that use of a dimethicone-degassed water mixture is simple, not expensive, safe, effective, and may reduce frequency of sonographic distortion in presence of air bubbles [5]. As the Figure 1 showed, Ultrasound image of both techniques in the same patient. A. Presence of artifact caused by air bubble while using conventional degassed water. B. Absence of artifacts when using degassed aqueous solution with dimethicone

Fig. 1 Ultrasound image of both techniques in the same patient

Renference

1 Rodriguez KJ, Cunningham C, Foxenberg R, Hoffman D, et al. The science behind wet wipes for infant skin: Ingredient review, safety and efficacy [J]. 2020, 37(3): 447-454.

2 Ihde E S, Boscamp J R, Loh J M, et al. Safety and efficacy of a 100% dimethicone pediculocide in school-age children[J]. BMC pediatrics, 2015, 15(1): 1-6.

3 Bergmann J F, Simoneau G, Chantelair G, et al. Use of dimethicone to reduce the fall in gastric potential difference induced by bile salts[J]. European journal of clinical pharmacology, 1989, 36(4): 379-381.

4 Pellicoro C, Marsella R, Ahrens K. Pilot study to evaluate the effect of topical dimethicone on clinical signs and skin barrier function in dogs with naturally occurring atopic dermatitis[J]. Veterinary medicine international, 2013.

5 de la Portilla F, Ynfante I, Fernández A, et al. Improved quality of anorectal endoluminal ultrasonography using emulsion of dimethicone[J]. Diseases of the colon & rectum, 2003, 46(10): 1436-1437.

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