1H-Imidazole-4-carbaldehyde: properties, applications and safety

General Description

1H-Imidazole-4-carbaldehyde is a valuable chemical compound with diverse applications in organic synthesis, pharmaceuticals, and materials science. Its reactivity as a building block enables the synthesis of heterocyclic compounds and pharmaceutical intermediates, contributing to drug development for infectious diseases, neurological disorders, and cancer. Furthermore, its use in material science includes functionalized polymers and metal-organic frameworks. However, its handling requires strict safety measures due to potential skin, eye, and respiratory irritation, as well as sensitization and long-term health risks. Therefore, proper safety protocols such as wearing protective equipment, working in well-ventilated areas, and following appropriate storage and disposal procedures are crucial. Overall, 1H-Imidazole-4-carbaldehyde's significance lies in its versatile applications, but careful attention to safety is essential when working with this compound.

Figure 1. 1H-Imidazole-4-carbaldehyde

Properties

1H-Imidazole-4-carbaldehyde is a chemical compound with important properties and uses. It is a white to light yellow solid with a molecular formula of C4H4N2O and a molecular weight of 96.09 g/mol.  ICA is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds due to its versatile reactivity. It exhibits strong nucleophilic character, making it an important intermediate in the production of various heterocyclic compounds. Additionally, ICA has been found to possess antimicrobial and antifungal properties, which has led to its application in the development of new drugs and biologically active molecules. Furthermore, 1H-Imidazole-4-carbaldehyde is sensitive to air and light, and should be stored in a cool, dry place away from direct sunlight to prevent degradation. It is important to handle this compound with care due to its potential reactivity and toxicity. In conclusion, 1H-Imidazole-4-carbaldehyde is a valuable compound in organic synthesis, with wide-ranging applications in the pharmaceutical and agrochemical industries, while also possessing significant biological activities. ¹

Applications

1H-Imidazole-4-carbaldehyde is a versatile chemical compound with a wide range of applications in various fields. Due to its unique structure and properties, ICA has found extensive use in organic synthesis, pharmaceuticals, and materials science. In organic synthesis, 1H-Imidazole-4-carbaldehyde serves as a key building block for the preparation of diverse heterocyclic compounds and pharmaceutical intermediates. Its reactivity as an aldehyde and its imidazole ring make it a valuable precursor in the synthesis of complex organic molecules. In the pharmaceutical industry, 1H-Imidazole-4-carbaldehyde is utilized in the development of pharmaceutical drugs, especially those targeting infectious diseases, neurological disorders, and cancer. Its pharmacological activities and structural diversity contribute to its significance in drug discovery and development. Moreover, 1H-Imidazole-4-carbaldehyde has applications in material science, where it is employed in the preparation of functionalized polymers, ligands for coordination chemistry, and as a component in metal-organic frameworks. Overall, the multifaceted applications of 1H-Imidazole-4-carbaldehyde underscore its significance in diverse scientific and industrial domains. ²

Safety

1H-Imidazole-4-carbaldehyde is a chemical compound that presents significant safety concerns due to its highly reactive nature. When handling this compound, it is important to be aware of its potential to cause skin and eye irritation, as well as respiratory tract irritation. Prolonged or repeated exposure to 1H-Imidazole-4-carbaldehyde can also lead to sensitization, causing allergic reactions in some individuals. Furthermore, long-term exposure to this compound has been linked to an increased risk of cancer. To ensure safety when working with 1H-Imidazole-4-carbaldehyde, strict safety measures should be followed. This includes wearing appropriate personal protective equipment such as gloves, goggles, and respiratory protection to prevent skin and eye irritation, as well as respiratory harm. It is crucial to work with this compound in a well-ventilated area or under fume hood to minimize the risk of inhalation. Additionally, proper storage, handling, and disposal procedures should be implemented to prevent accidental exposure and environmental contamination. Overall, understanding and adhering to safety protocols are essential to mitigate the potential health hazards associated with 1H-Imidazole-4-carbaldehyde. ³

Reference

1. PubChem. COMPOUND SUMMARY: 1H-Imidazole-4-carbaldehyde. National Library of Medicine, PubChem CID: 76428.

2. CHORNOUS V. Synthesis and Biological Activity of 4-Chloro-1H-Imidazole-5-Carbaldehyde Thiosemicarbazones. Pharmaceutical Chemistry Journal, 2014, 47: 524-526.

3. 1H-imidazole-4-carbaldehyde. European Chemicals Agency, EC / List no. 221-227-3.

You may like