Targeted Drug Inhibitors Mk-1775 CAS 955365-80-7 for Treat Ovarian Cancer

Mk-1775

湖北更新日期：2018-06-27

Wuhan Biocar Bio-Pharm Co.Ltd.

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产品详情:

中文名称：: Targeted Drug Inhibitors Mk-1775 CAS 955365-80-7 for Treat Ovarian Cancer

英文名称：: Mk-1775

CAS号：: 955365-80-7

品牌：: Besteroids

产地：: Hubei

纯度规格：: Pharmaceutical Grade

Targeted Drug Inhibitors Mk-1775 CAS 955365-80-7 for Treat Ovarian Cancer

Basic Info.

Model NO.: 955365-80-7

Suitable for: Adult

Purity: >99%

Product Name: Mk-1775

Delivery: Safe & Timely, Around 7days After Payment.

Specification: 1kg foil bag or as require

Powder: Yes

State: Solid

Assay: 99%

Description: Yellow Powder

Alias: Mk1775

Transport Package: Discreet Package for Delivery Guarantee

MK-1775 Description:

MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. MK-1775 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow. MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.

MK-1775 Applicaiton:

MK-1775 inhibits Wee1 kinase in an ATP-competitive manner. Compared to Wee1, MK-1775 displays 2- to 3-fold less potency against Yes with IC50 of 14 nM, 10-fold less potency against seven other kinases with >80% inhibition at 1 μM, and >100-fold selectivity over human Myt 1, another kinase that inhibits cyclin-dependent kinase 1 (CDC2) by phosphorylation at an alternative site (Thr14). By abrogating the DNA damage checkpoint via blockade of Wee1 activity in WiDr cells bearing mutated p53, MK-1775 treatment inhibits the basal phosphorylation of CDC2 at Tyr15 (CDC2Y15) with EC50 of 49 nM, and suppresses gemcitabine-, carboplatin- or cisplatin-induced phosphorylation of CDC2 and cell cycle arrest in a dose-dependent manner, with EC50 of 82 nM and 81 nM, 180 nM and 163 nM, as well as 159 nM and 160 nM, respectively. MK-1775 treatment alone at 30-100 nM has no significant antiproliferative effect in WiDr and H1299 cells, whereas MK-1775 at 300 nM, sufficient to inhibit Wee1 by >80%, displays moderate but significant antiproliferative effects by 34.1% in WiDr cells and 28.4% in H1299 cells.

Our Advantages:

1,High quality with competitive price:

1)Standard:BP/USP

2)All Purity≥99%

3)We are manufacturer and can provide high quality products with factory price.

2,Fast and safe delivery

1)Parcel can be sent out in 24 hours after payment.Tracking number available

2)Secure and discreet shipment.Various transportation methods for your choice.

3)Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

3,We have clients throughout the world.

1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.

2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.

3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers.

Mk-1775 ,sarms powder,Treat Ovarian Cancer

公司简介

Biocar is a leading manufacturer and supplier of Anabolic Steroid Hormone Powders, Pharmaceutical raw materials, Pharmaceutical Intermediates. After decades years with the experts and professors from Wuhan University, Wuhan Institute of Technology and HUST we estabilished a group of technical experts, optimize the steroid synthetic and green production process to ensure that Biocar production technology in a leading international Level. Biocar steroid products have certified by GMP and COS, sales network spread over the countries in Asia, Europe, North America, South America. Wuhan Bioc

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