Anti-Phospho-SHIP1 (Tyr1020) antibody-磷酸化SH2结构含磷酸肌醇SHIP1抗体

Rabbit  Anti-Phospho-SHIP1 (Tyr1020) Polyclonal Antibody
DATASHEET

Host:Rabbit

Target Protein:Phospho-SHIP1 (Tyr1020)

IR:Immunogen Range:PL(p-Y)GS

Clonality:Polyclonal

Isotype:IgG

Entrez Gene:65038

Swiss Prot:P97573

Source:KLH conjugated Synthesised phosphopeptide derived from rat SHIP1 around the phosphorylation site of Tyr1020:PL(p-Y)GS 

Purification:affinity purified by Protein A

Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.

Size:50ul

Concentration:1mg/ml

Applications:WB(1:500-2000)
ELISA(1:5000-10000)

Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow

仅供科研使用。不能用于人和动物治疗等其它临床诊断用！