普健生物（武汉）科技有限公司

标题：Research Grade Vatreptacog alfa对照抗体,AntibodySystem Laboratories

链接：https://www.antibodysystem.com/product/19169.html

名称：Research Grade Vatreptacog alfa对照抗体

别名：rFVIIa analog NN1731, FVIIa DVQ, Eptacog Alfa

货号：DHC35901

适用物种：Human

存储缓冲区：0.01M PBS, pH 7.4.

浓度：1 mg/ml

形式：Liquid

纯度：>95%

克隆：Monoclonal

同型：A recombinant factor VIIa (rFVIIa) analog with three amino acid substitutions (Asp158Val, Val296Glu, and Glu298Met).

应用：Research Grade Biosimilar

靶点：F7, Proconvertin, SPCA, Serum prothrombin conversion accelerator, Coagulation factor VII, Eptacog alfa

内毒素水平：Please contact with the lab for this information.

UniProt：P08709

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

产品购买联系方式：027-65279366 /18162686757

邮箱：biolab-reagents@atagenix.com

QQ：2663991332

参考文献：

Vatreptacog alfa from conception to clinical proof of concept. PMID: 22510860

Recombinant factor VIIa analog (vatreptacog alfa [activated]) for treatment of joint bleeds in hemophilia patients with inhibitors: a randomized controlled trial. PMID: 22470921

Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity. PMID: 26362483

Recombinant factor VIIa analog in the management of hemophilia with inhibitors: results from a multicenter, randomized, controlled trial of vatreptacog alfa. PMID: 24931322

Overcoming delayed in-vitro response to rFVIIa: effects of rFVIIa and rFVIIa analogue (vatreptacog alfa) concentration escalation in whole blood assays. PMID: 21681082

The MHC Associated Peptide Proteomics assay is a useful tool for the non-clinical assessment of immunogenicity. PMID: 37915568

Hemostatic properties of the FVIIa analog NN1731. PMID: 22446168

Mitigation of T-cell dependent immunogenicity by reengineering factor VIIa analogue. PMID: 31506285

Pharmacokinetics and pharmacodynamics of rFVIIa and new improved bypassing agents for the treatment of haemophilia. PMID: 22757678

Post hoc assessment of the immunogenicity of bioengineered factor VIIa demonstrates the use of preclinical tools. PMID: 28077675

The effect of acylation with fatty acids and other modifications on HLA class II:peptide binding and T cell stimulation for three model peptides. PMID: 29758051