Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
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4-(4-Hydroxy-3-methoxyphenyl)butan-2-one(122-48-5)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
4-(4-Hydroxy-3-methoxyphenyl)butan-2-one
Synonyms
(4-Hydroxy-3-methoxyphenyl)ethyl methyl ketone
4-(3-Methoxy-4-hydroxyphenyl)-2-butanone
4-(4-Hydroxy-3-methoxyphenyl)-2-butanone
4-Hydroxy-3-methoxybenzylacetone
Ethyl 2-picolinate
Ethyl pyridine-2-carboxylate
Gingerone
Vanillylacetone
CAS
2524-52-9
CAS
122-48-5
Formula
C11H14O3
Formula
C8H9NO2
Molecular Weight
151.16999999999999
Molecular Weight
194.23
EINECS
204-548-3
EINECS
219-758-0
RTECS
EL8900000
RTECS Class
Natural Product; Primary Irritant
Merck
12,10301
Beilstein/Gmelin
122485
Beilstein/Gmelin
2051099
Beilstein Reference
4-08-00-01866
Beilstein Reference
5-22-02-00004

Physical and Chemical Properties

Appearance
Clear slightly yellow liquid.
Appearance
Crystals from acetone, petroleum ether, ether plus petroleum ether strong, pungent odor reminiscent of ginger.
Solubility in water
Insoluble
Solubility in water
Slightly soluble
Melting Point
40
Melting Point
1 - 3
Boiling Point
126 (0.4 torr)
Boiling Point
240
Vapor Pressure
0.03 (25 C)
Density
1.122 g/cm3 (17.5 C)
Density
1.138-1.139 g/cm3 (25 C)
pKa/pKb
11.77 (pKb)
Partition Coefficient
1.04
Heat Of Vaporization
48.1
Usage
Flavor ingredient.
Vapor Density
5.21
Refractive Index
1.5104 (20 C)

First Aid Measures

Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Ingestion
Seek medical assistance.
Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Skin
May cause skin irritation.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Skin
Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush with running water for at least 20 minutes. Wash skin with soap and water.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.
Eyes
May cause eye irritation.

Handling and Storage

Storage
Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Ingestion
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation
Ingestion of significant amounts may cause respiratory depression. Pulmonary aspiration may result in chemical pneumonitis.
Skin
Skin exposure to the liquid or vapor may result in dermatitis and paresthesias of affected areas. Contact urticaria has also been reported.
Eyes
See Skin.
Ingestion
Nausea and vomiting may occur.
EC Risk Phrase
R 36/38
EC Safety Phrase
S 26 36
UN (DOT)
1325

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Personal Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Exposure Effects
Limited studies have generally documented little or no effect of ketones on reproduction in experimental animals. Human data is lacking. 2,5-Hexanedione has an effect on spermatogenesis in male experimental animals.

Fire Fighting Measures

Flash Point
107
Fire Fighting
Small Fires: Dry chemical, carbon dioxide, sand, earth, water spray or regular foam. Large Fires: Water spray, fog or regular foam.
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Containers may explode when heated. Extinguishing media: Use agent most appropriate to extinguish fire. Cool containers with flooding quantities of water until well after fire is out. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire Potential
Flammable/combustible material. May be ignited by friction, heat, sparks or flames.

Accidental Release Measures

Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation.
Small spills/leaks
Make no contact with the spilled material. ELIMINATE all ignition sources and ground all equipment. With clean shovel place material into clean, dry container and cover loosely; move containers from spill area.

Stability and Reactivity

Disposal Code
5
Stability
No data.
Incompatibilities
Oxidizing agents.
Stability
Stable under normal temperatures and pressures.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Combustion Products
Fire may produce irritating and/or toxic gases.

Transport Information

UN Number
1325
Hazard Class
4.1
Packing Group
II; III
HS Code
2933 39 99
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