Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Ubenimex(58970-76-6)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Ubenimex
Synonyms
3-(R)-Amino-2-(S)-hydroxy-4-phenylbutanoyl-(S)-leucine
Bestatin
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine
NK-421
CAS
58970-76-6
Formula
C16H24N2O4
Molecular Weight
308.38
EINECS
261-529-2
RTECS
OH2915000
RTECS Class
Drug; Reproductive Effector; Natural Product
Merck
12,9973
Beilstein/Gmelin
4704312
Beilstein Reference
6-14

Physical and Chemical Properties

Appearance
white powder
Solubility in water
Soluble
Melting Point
231 - 234
Vapor Pressure
2E-15 (25 C)
pKa/pKb
3.60 (pKa)
Heat Of Vaporization
94.5 kJ/mol
Usage
An aminopeptidase inhibitor used in combination with chemotherapeutics for the maintenance and enhancement of complete remission of acute non-lymphocytic leukemia in adults.

First Aid Measures

Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage
Keep tightly closed.

Hazards Identification

Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
Skin
May cause skin irritation. May be harmful if absorbed through the skin.
Eyes
May cause eye irritation.
Ingestion
May be harmful if swallowed.
Hazards
Emits toxic fumes under fire conditions.
EC Safety Phrase
22 24/25

Exposure Controls/Personal Protection

Personal Protection
Protective gloves. Chemical safety goggles.
Respirators
Wear dust mask.
Exposure Effects
The chemical, physical, and toxicological properties of this product have not been thoroughly investigated. Exercise due care.

Fire Fighting Measures

Flash Point
320
Fire Fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.
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