Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Domperidone(57808-66-9)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Domperidone
Synonyms
4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine
5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
KW-5338
Motilium
Peridon
CAS
57808-66-9
Formula
C22H24ClN5O2
Molecular Weight
425.92
EINECS
260-968-7
RTECS
DE2275900
RTECS Class
Drug; Reproductive Effector; Human Data
Merck
12,3476
Beilstein/Gmelin
903774
Beilstein Reference
5-24-02-00402

Physical and Chemical Properties

Appearance
White powder.
Solubility in water
Insoluble
Melting Point
236 - 239
pKa/pKb
4.80 (pKb)
Usage
Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.

First Aid Measures

Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage
Keep tightly closed.

Hazards Identification

Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
Skin
May cause skin irritation. May be harmful if absorbed through the skin.
Eyes
May cause eye irritation.
Ingestion
May be harmful if swallowed.
Hazards
Emits toxic fumes under fire conditions.

Exposure Controls/Personal Protection

Personal Protection
Compatible chemical-resistant gloves.
Respirators
Government approved respirator.
Exposure Effects
Harmful. Possible risk of harm to the unborn child. Possible risk of impaired fertility. Target organ(s): G.I. System.

Fire Fighting Measures

Fire Fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.
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