Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Doxycycline(564-25-0)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Doxycycline
Synonyms
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
6-Deoxy-5-hydroxytetracycline
6-Deoxytetracycline
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
Doxycyclin hyclate
CAS
564-25-0
Formula
C22H24N2O8
Molecular Weight
444.44
EINECS
209-271-1
RTECS
QI8650000
RTECS Class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,3496
Beilstein/Gmelin
2230419

Physical and Chemical Properties

Appearance
Yellow, crystalline powder with slight ethanolic odor.
Solubility in water
Slightly soluble
Vapor Pressure
2E-24 (25 C)
pKa/pKb
4.50 (pKa)
Partition Coefficient
-.26
Usage
Medication.

First Aid Measures

Ingestion
Flush mouth out with water. Seek medical attention.
Inhalation
Remove to fresh air.
Skin
Flush with copious amounts of water for at least 15 minutes.
Eyes
Flush with copious amounts of water for at least 15 minutes.

Handling and Storage

Storage
store in a tightly closed container.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation
Allergic reaction. Irritation.
Skin
Skin hyperpigmentation has been reported.
Eyes
Irritation.
Ingestion
Nausea, vomiting, epigastric burning, and abdominal discomfort have been noted. Tetracycline and doxycycline have been implicated in causing esophageal ulceration, but this is thought to be uncommon.

Exposure Controls/Personal Protection

Personal Protection
Rubber or vinyl gloves, safety goggles and appropriate laboratory clothings.
Respirators
NIOSH approved respirator.
Exposure Effects
Headache, papilledema and benign intracranial hypertension have been reported. Maternal ingestion of tetracyclines during pregnancy may cause tooth discoloration, enamel defects, and other congenital anomalies. <br>Hepatotoxicity, pancreatitis, and renal failure may occur in pregnant women following ingestion of tetracyclines during pregnancy.

Fire Fighting Measures

Fire Fighting
Evacuate area. Wear SCBA and protective clothing. Use agent most suitable for extinguishing surrounding fire.

Accidental Release Measures

Small spills/leaks
Wear dust respirator and rubber gloves. Sweep up, avoiding dust generation. Place in appropriate container for disposal.

Stability and Reactivity

Stability
Stable at normal temperatures and pressures.
Decomposition
Toxic fumes.
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