Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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PGE2(363-24-6)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
PGE2
Synonyms
7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
7-(3-HydroxyProsta-5,13-dien-1-oic acid, (5Z,11-alpha,13E,15S)-11,15-dihydroxy-9-oxo-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
Cerviprost
Dinoprostone
Glandin
Minprositin E2
CAS
363-24-6
Formula
C20H32O5
Molecular Weight
352.47
EINECS
206-656-6
RTECS
UK8000000
RTECS Class
Drug; Mutagen; Reproductive Effector; Human Data; Hormone
Merck
12,8064
Beilstein/Gmelin
2224724

Physical and Chemical Properties

Appearance
White crystals.
Solubility in water
Slightly soluble
Melting Point
70
Density
1.114 g/cm3
pKa/pKb
4.76 (pKa)
Usage
Induction of labor.

First Aid Measures

Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if symptoms occur.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Handling and Storage

Storage
Keep container closed when not in use. Deep freeze (below -20 C). Store protected from light. Store with dessicant.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light. Use only in a chemical fume hood.

Hazards Identification

Inhalation
The toxicological properties of this substance have not been fully investigated. May cause irritation of the mucous membranes.
Skin
May cause skin irritation. The toxicological properties of this material have not been fully investigated.
Eyes
May cause eye irritation. The toxicological properties of this material have not been fully investigated.
Ingestion
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed. Other effects include headache, flushing, shivering and dizziness.

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Exposure Effects
Chronic exposure may cause reproductive disorders and teratogenic effects. May cause termination of pregnancy.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use carbon dioxide, dry chemical powder or appropriate foam.

Accidental Release Measures

Small spills/leaks
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities
Acids, bases.
Stability
Stable under normal temperatures and pressures. Light sensitive.
Decomposition
Carbon monoxide, carbon dioxide, acrid smoke and fumes.
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