Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Etoposide(33419-42-0)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Etoposide
Synonyms
(-)-Etoposide, (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside)
9-((4,6-O-Ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one
Lastet
Toposar
VePesid
CAS
33419-42-0
Formula
C29H32O13
Molecular Weight
588.57000000000005
EINECS
251-509-1
RTECS
KC0190000
RTECS Class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,3931
Beilstein/Gmelin
3659695

Physical and Chemical Properties

Appearance
Typically in the form of pink, liquid fillled, soft gelatin capsules.
Solubility in water
approx 0.08 mg/ml
Melting Point
262 - 263
pKa/pKb
9.8(at 25℃) (pKa)
Usage
Medication.

First Aid Measures

Ingestion
Seek immediate medial attention.
Inhalation
Seek immediate medial attention.
Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Handling and Storage

Storage
Store under refrigeration, in orginal container.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation
Dyspnea, acute bronchospasm, apnea and cyanosis have been reported. Fatal pulmonary toxicity has been reported after oral use.
Skin
Rash, urticaria and/or pruritus have been infrequently reported. Erythema and desquamation, alopecia, onycholysis, and stevens-johnson syndrome have occurred following therapeutic use of etoposide.
Eyes
Conjunctivitis.
Ingestion
Ausea, vomiting and diarrhea commonly occur. Paralytic ileus has been reported.

Exposure Controls/Personal Protection

Personal Protection
Surgical latex gloves -- which should be changed regularly. Safety goggles.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Exposure Effects
Bone marrow supression. Cytotoxic agent. Anaphlactic-like reaction is possible. Possible carcinogen.

Fire Fighting Measures

Fire Fighting
Wear SCBA and full protective clothing. Extinguish fire with water, COT or dry chemical powder.

Accidental Release Measures

Small spills/leaks
Scoop up material and place in container for later disposal.

Stability and Reactivity

Stability
Stable under normal storage and usage conditions. Avoid elevated temperatures.
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