Home > Cyproheptadine > Cyproheptadine(129-03-3)
Cyproheptadine(129-03-3)
Supplier Product Identification
Physical and Chemical Properties
First Aid Measures
Handling and Storage
Hazards Identification
Exposure Controls/Personal Protection
Fire Fighting Measures
Accidental Release Measures
Stability and Reactivity
Transport Information
Product Identification
Product Name
Cyproheptadine
Cyproheptadine
Synonyms
1-Methyl-4-(5H-dibenzo[a,d]cycloheptenylidene)piperidine
1-Methyl-4-(dibenzo[a,e]cycloheptatrien-5-ylidene)piperidine
1-Phenylethanone
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine
Acetylbenzene
Cyproheptadine
Methyl phenyl ketone
Phenyl methyl ketone
Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-
1-Methyl-4-(5H-dibenzo[a,d]cycloheptenylidene)piperidine
1-Methyl-4-(dibenzo[a,e]cycloheptatrien-5-ylidene)piperidine
1-Phenylethanone
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine
Acetylbenzene
Cyproheptadine
Methyl phenyl ketone
Phenyl methyl ketone
Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-
CAS
129-03-3
129-03-3
CAS
98-86-2
98-86-2
Formula
C21H21N
C21H21N
Formula
C8H8O
C8H8O
Molecular Weight
120.15
120.15
Molecular Weight
287.39999999999998
287.39999999999998
EINECS
202-708-7
202-708-7
EINECS
204-928-9
204-928-9
RTECS
AM5250000
AM5250000
RTECS
TM7000000
TM7000000
RTECS Class
Mutagen; Primary Irritant
Mutagen; Primary Irritant
RTECS Class
Drug; Mutagen; Reproductive Effector
Drug; Mutagen; Reproductive Effector
Merck
12,2842
12,2842
Merck
13,74
13,74
Beilstein/Gmelin
1685976
1685976
Beilstein/Gmelin
605842
605842
Beilstein Reference
4-07-00-00619
4-07-00-00619
Beilstein Reference
5-20-08-00500
5-20-08-00500
EC Index Number
606-042-00-1
606-042-00-1
EC Class
Harmful; Irritant
Harmful; Irritant
Physical and Chemical Properties
Appearance
Colorless liquid, sweet, almond odor.
Colorless liquid, sweet, almond odor.
Appearance
Crystals from dil ethanol.
Crystals from dil ethanol.
Solubility in water
5.5 g/L
5.5 g/L
Solubility in water
Insoluble
Insoluble
Melting Point
116.5 - 118
116.5 - 118
Melting Point
20
20
Boiling Point
201.7
201.7
Vapor Pressure
0.3 (25 C)
0.3 (25 C)
Density
1.027 g/cm3 (20 C)
1.027 g/cm3 (20 C)
pKa/pKb
5.30 (pKb)
5.30 (pKb)
Partition Coefficient
1.58
1.58
Heat Of Vaporization
49.0 kJ/mol
49.0 kJ/mol
Usage
Medication.
Medication.
Usage
In perfumery to impart an orange-blossom-like odor, catalyst for polymerization of olefins, in organic synthesis, esp as photosensitizer.
In perfumery to impart an orange-blossom-like odor, catalyst for polymerization of olefins, in organic synthesis, esp as photosensitizer.
Saturation Concentration
Approximately 1300 ppm (0.13%) at 20 C (calculated)
Approximately 1300 ppm (0.13%) at 20 C (calculated)
Odor threshold
0.01-0.025 mg/m3
0.01-0.025 mg/m3
Refractive Index
1.5339 (20 C)
1.5339 (20 C)
First Aid Measures
Ingestion
Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed.
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed.
Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Inhalation
Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Material has a low vapor pressure, so exposure to vapor is not likely.
Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Material has a low vapor pressure, so exposure to vapor is not likely.
Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Skin
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Skin
Causes skin irritation.
Causes skin irritation.
Eyes
May cause transient corneal injury. Causes severe eye irritation and possible injury.
May cause transient corneal injury. Causes severe eye irritation and possible injury.
Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.
Handling and Storage
Storage
Keep away from heat and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Keep away from heat and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Storage
Store below 40C (104F), preferably between 15 and 30C (59 and 86F), unless otherwise specified by manufacturer. Store in a well-closed container.
Store below 40C (104F), preferably between 15 and 30C (59 and 86F), unless otherwise specified by manufacturer. Store in a well-closed container.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Use spark-proof tools and explosion proof equipment. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Use spark-proof tools and explosion proof equipment. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Hazards Identification
Inhalation
Pneumonitis, chest tightness, and wheezing have been reported.
Pneumonitis, chest tightness, and wheezing have been reported.
Skin
Skin may be flushed, warm and dry after overdose.
Skin may be flushed, warm and dry after overdose.
Eyes
Anticholinergic effects, such as prolonged dialation of the pupils, nasal dryness and stuffiness, and mouth and throat dryness, can occur with overdose or therapeutic use.
Anticholinergic effects, such as prolonged dialation of the pupils, nasal dryness and stuffiness, and mouth and throat dryness, can occur with overdose or therapeutic use.
Ingestion
Overdose may cause anticholinergic effects of ileus and diminished bowel sounds. Nausea, vomiting, and loss of appetite may occur .
Overdose may cause anticholinergic effects of ileus and diminished bowel sounds. Nausea, vomiting, and loss of appetite may occur .
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
EC Risk Phrase
R 22 36
R 22 36
EC Safety Phrase
S 26
S 26
UN (DOT)
1993
1993
Exposure Controls/Personal Protection
Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Exposure Effects
Prolonged or repeated eye contact may cause conjunctivitis. Prolonged or repeated skin contact may cause defatting and dermatitis. Laboratory experiments have resulted in mutagenic effects. Narcotic in high concentrations.
Prolonged or repeated eye contact may cause conjunctivitis. Prolonged or repeated skin contact may cause defatting and dermatitis. Laboratory experiments have resulted in mutagenic effects. Narcotic in high concentrations.
Exposure Effects
Rapid heart rate is common. Elevated body temperature, abnormally low blood pressure, and elevated blood pressure have been reported. overdose may result in either CNS depression, including coma, or CNS stimulation, such as toxic psychosis. Subsequent seizures are not uncommon, especially in children. A higher incidence of seizures has been reported following pheniramine overdoses. Therapeutic use has been associated with acute dystonic reactions and dyskinesias. In general, there have been few reported teratogenic effects in humans, although animal studies have suggested that certain antihistamines have teratogenic potential. <br>Pyloric stenosis has occurred in infants following maternal use of antihistamines. <br>Small amounts of antihistamines are excreted in breast milk.
Rapid heart rate is common. Elevated body temperature, abnormally low blood pressure, and elevated blood pressure have been reported. overdose may result in either CNS depression, including coma, or CNS stimulation, such as toxic psychosis. Subsequent seizures are not uncommon, especially in children. A higher incidence of seizures has been reported following pheniramine overdoses. Therapeutic use has been associated with acute dystonic reactions and dyskinesias. In general, there have been few reported teratogenic effects in humans, although animal studies have suggested that certain antihistamines have teratogenic potential. <br>Pyloric stenosis has occurred in infants following maternal use of antihistamines. <br>Small amounts of antihistamines are excreted in breast milk.
Exposure limit(s)
TLV: 10 ppm; 49 mg/m3 (ACGIH 1993-1994).
TLV: 10 ppm; 49 mg/m3 (ACGIH 1993-1994).
Poison Class
4
4
Fire Fighting Measures
Flash Point
82
82
Autoignition
570
570
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Containers may explode when heated. Extinguishing media: Use water spray to cool fire-exposed containers. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Containers may explode when heated. Extinguishing media: Use water spray to cool fire-exposed containers. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Upper exp. limit
5.2
5.2
Lower exp. limit
1.4
1.4
Fire Potential
Slight when exposed to head or flame.
Slight when exposed to head or flame.
Accidental Release Measures
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability and Reactivity
Stability
Relatively stable in light, stable @ room temperature.
Relatively stable in light, stable @ room temperature.
Stability
Stable under normal temperatures and pressures.
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, strong bases, strong reducing agents, aldehydes, nitric acid + hydrogen peroxide, perchloric acid.
Strong oxidizing agents, strong bases, strong reducing agents, aldehydes, nitric acid + hydrogen peroxide, perchloric acid.
Incompatibilities
Strong oxidizing agents.
Strong oxidizing agents.
Disposal Code
3
3
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.
Fire may produce irritating, corrosive and/or toxic gases.
Transport Information
UN Number
1993
1993
Hazard Class
3
3
Packing Group
I; II; III
I; II; III
HS Code
2914 39 00
2914 39 00
Contact
More
- Company Name:LGM Pharma
- Tel:1-(800)-881-8210
- Fax:615-250-9817
- WebSite:http://www.lgmpharma.com
- Company Name:Beijing HuaMeiHuLiBiological Chemical
- Tel:010-56205725
- Fax:010-65763397
- WebSite:http://www.huabeibiochem.com/
- Company Name:Shanghai T&W Pharmaceutical Co., Ltd.
- Tel:+86 21 61551611
- Fax:+86 21 50676805
- WebSite:http://www.trustwe.com
- Company Name:JinJin Le Chemical Co., Ltd
- Tel:10106090
- Fax:
- WebSite:http://www.jinjinlechem.com
- Company Name:Aikon International Limited
- Tel:025-58859352 18068836627
- Fax:02557626880
- WebSite:http://www.aikonchem.com