Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Hazards Identification
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Formestane(566-48-3)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Hazards Identification

Product Identification

Product Name
Formestane
Synonyms
4-Hydroxy-4-androstene-3,17-dione
4-Hydroxy-delta(sub 4)-androstenedione
CGP-32349
CAS
566-48-3
Formula
C19H26O3
Molecular Weight
302.41000000000003
RTECS
BV8152500
Merck
12,4267
Beilstein/Gmelin
1889793

Physical and Chemical Properties

Appearance
White powder.
Solubility in water
Insoluble
Melting Point
199 - 202
Vapor Pressure
4.9E-11 (25 C)
Density
1.19 g/cm3 (20 C)
pKa/pKb
9.31 (pKa)
Partition Coefficient
2.66
Usage
Used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women.

First Aid Measures

Ingestion
If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.
Inhalation
Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.
Skin
Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.
Eyes
Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.

Handling and Storage

Storage
Store cool, dark and dry.

Exposure Controls/Personal Protection

Personal Protection
Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves.
Exposure Effects
Harmful by inhalation, in contact with skin and if swallowed.

Fire Fighting Measures

Fire Fighting
Extinguish with carbon dioxide, dry chemical powder or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.

Accidental Release Measures

Small spills/leaks
Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pickup is complete.

Stability and Reactivity

Combustion Products
Emits toxic fumes under fire conditions.

Hazards Identification

EC Risk Phrase
R: 20/21/22
EC Safety Phrase
S: 36/37
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