Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Ethyl 2-(4-chlorophenoxy)-2-methylpropionate(637-07-0)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Ethyl 2-(4-chlorophenoxy)-2-methylpropionate
Synonyms
2-(P-chlorophenoxy)-2-methylpropionic*acid ethyl
Antilipid
Ateculon
Ethyl 2-(4-chlorophenoxy)-2-methylpropionate
Ethyl clofibrate
Phenoxyisobutyricacidethylester
CAS
637-07-0
Formula
C12H15ClO3
Molecular Weight
242.7
EINECS
211-277-4
RTECS
UE9480000
RTECS Class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,2436
Beilstein/Gmelin
1913459
Beilstein Reference
4-06-00-00851

Physical and Chemical Properties

Appearance
Oil. Faint characteristic odor.
Solubility in water
insoluble
Boiling Point
148
Density
1.138-1.144 g/cm3 (20 C)
Usage
Agent to lower plasma very-low-density-lipoprotein concn, agent to lower concn of plasma triglycerides.
Refractive Index
1.505 (19 C)

First Aid Measures

Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage
Clofibrate liquid-filled capsules should be stored in well-closed, light-resistant containers, at a temperature less than 40C. Preferably at 15-30C; freezing of the liquid-filled capsules should be avoided.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Skin
Various rashes and alopecia have been reported.
Ingestion
Ausea, vomiting, constipation, dyspepsia, diarrhea, and flatulence occur transiently in approximately 10% of patients. Epigastric pain has been reported as a frequent side effect and cholelithiasis is increased.

Exposure Controls/Personal Protection

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Exposure Effects
with therapeutic use - fatigue, weakness, drowsiness, dizziness, and headache have been reported during clofibrate therapy. Clofibrate and Fenofibrate are classified as FDA Pregnancy Category C.

Fire Fighting Measures

Flash Point
110
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability
Sensitive to oxidation and light; easily hydrolyzed.
Incompatibilities
Strong oxidizing agents.
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