Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
Home > 9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide > 9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide(76-25-5)

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide(76-25-5)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide
Synonyms
2-Amino-5-methylbenzoic acid
2-Carboxy-4-methylaniline
5-Methyl-2-aminobenzoic acid
5-Methylanthranilic acid
9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide
9-a-fluoro-11-b,21-dihydroxy-16-a,17-a-isopropylidenedioxypregna-1,4-diene-3,20-dione
9a-Fluoro-16a,17a-isopropylidenedihydroxyprednisolone
9a-Fluoro-16a-hydroxyprednisolone 16a,17a-acetonide
Kenalog
Polcortoon
CAS
2941-78-8
CAS
76-25-5
Formula
C24H31FO6
Formula
C8H9NO2
Molecular Weight
434.5
Molecular Weight
151.16
EINECS
200-948-7
EINECS
220-932-3
RTECS
TU3920000
RTECS Class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,9728
Beilstein/Gmelin
1101527
Beilstein/Gmelin
60069
Beilstein Reference
5-19-06-00568
Beilstein Reference
4-14-00-01357

Physical and Chemical Properties

Appearance
Beige - light brown powder.
Solubility in water
Insoluble
Solubility in water
Very soluble
Melting Point
274
Boiling Point
317
Boiling Point
577
Vapor Pressure
0.0002 (25 C)
Vapor Pressure
1E-15 (25 C)
pKa/pKb
2.08 (pKa)
pKa/pKb
12.69 (pKs)
Partition Coefficient
1.67
Heat Of Vaporization
58.9 kJ/mol
Heat Of Vaporization
99.2 kJ/mol
Usage
A synthetic corticosteroid. Used for replacement therapy in people whose adrenal glands are not producing enough natural steroids (adrenal insufficiency) and decreasing inflammation in certain disease states. .
Usage
Metabolic antagonist.

First Aid Measures

Ingestion
Get medical aid. Wash mouth out with water.
Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
Inhalation
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin
Causes skin irritation.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
Eyes
Causes eye irritation.

Handling and Storage

Storage
Keep tightly closed.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

Hazards Identification

Ingestion
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
Skin
May cause skin irritation. May be harmful if absorbed through the skin.
Eyes
May cause eye irritation.
Ingestion
May be harmful if swallowed.
Hazards
Emits toxic fumes under fire conditions.
EC Risk Phrase
R 36/37/38
EC Safety Phrase
S 26 36
EC Safety Phrase
22 24/25

Exposure Controls/Personal Protection

Personal Protection
Protective gloves. Chemical safety goggles.
Personal Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Wear dust mask.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Exposure Effects
Avoid contact and inhalation. Target organ(s): Endocrine system.

Fire Fighting Measures

Flash Point
145
Flash Point
303
Fire Fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability
No data.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Hydrogen fluoride.
Decomposition
Carbon monoxide, oxides of nitrogen, carbon dioxide.
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