Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Ketamine hydrochloride(1867-66-9)

Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Ketamine hydrochloride
Synonyms
(+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Calipsol
CI 581
Kalipsol
Ketaset
Vetalar
CAS
1867-66-9
Formula
C13H16ClNO.ClH
Molecular Weight
274.20999999999998
EINECS
217-484-6
RTECS
GW1400000
RTECS Class
Drug; Mutagen; Reproductive Effector; Human Data
Beilstein/Gmelin
5318526
Beilstein Reference
6-14

Physical and Chemical Properties

Appearance
Colorless to white crystals.
Solubility in water
0.2 g/mL (20 C)
Melting Point
262 - 263
pKa/pKb
7.5(at 25℃) (pKa)
Usage
Medication. Selective nmda glutamate receptor antagonist; veterinary anesthetic.

First Aid Measures

Ingestion
Benzodiazepines or droperidol and minimization of sensory stimuli may reduce the incidence of psychotomimetic effects of ketamine. Administer oxygen and manage airway as clinically indicated.
Inhalation
See ingestion.
Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists.
Eyes
Irrigate eye for at least 20 minutes with water or saline. If irritation persists, seek medical attention.

Handling and Storage

Storage
Keep tightly closed. Store at 2-8 C

Hazards Identification

Inhalation
Respiratory depression, apnea, and respiratory arrest may occur. Ketamine may produce bronchodilation and increased salivary and tracheobronchial secretions.
Skin
May be harmful if absorbed through the skin.
Eyes
Temporary loss of vision or blurred vision may be noted.
Ingestion
Nausea and vomiting have been reported.
Hazards
Emits toxic fumes under fire conditions.
EC Risk Phrase
22 36/37/38 40
EC Safety Phrase
26 36

Exposure Controls/Personal Protection

Personal Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Exposure Effects
Sedation and respiratory depression have been reported after overdose in medical settings. Patients usually awaken within a few hours, although sedation lasting 24 hours has been described. Ketamine has become a drug of abuse. Common effects include tachycardia, altered mental status, anxiety, palpitations, slurred speech hallucinations, nystagmus, mydriasis, mild hypertension and chest pain. Confusion, vomiting and memory loss are less common. Rarely seizures, polyneuropathy, or respiratory arrest may occur. Death is rare following ketamine abuse or overdose.

Fire Fighting Measures

Fire Fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Incompatibilities
Oxidizing agents.
Stability
Stable at normal temperatures and pressures.
Decomposition
When heated to decomposition, the material emits fumes of HCl and NOx.