Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Chlorthalidone(77-36-1)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Chlorthalidone
Synonyms
1-keto-3-(3'-Sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline
2-Chloro-5-(3-hydroxy-1-oxoisoindol-3-yl)benzenesulfonamide
3-Hydroxy-3-[4-chloro-3-sulfamylphenyl]phthalimidine
Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-
Demi-Regroton
Natriuran
CAS
77-36-1
Formula
C14H11ClN2O4S
Molecular Weight
338.77
EINECS
201-022-5
RTECS
DB1556000
RTECS Class
Reproductive Effector; Human Data
Merck
12,2246
Beilstein/Gmelin
312295
Beilstein Reference
5-22-07-00602

Physical and Chemical Properties

Appearance
White to yellowish-white crystalline powder. Odorless.
Solubility in water
Slightly soluble
Melting Point
179
pKa/pKb
4.43 (pKb)
Usage
Therap cat (vet): diuretic.

First Aid Measures

Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage
Keep in airtight container.
Handling
Use in hood. Wear protective equipment. Do not raise dust.

Exposure Controls/Personal Protection

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
None is normally required. If needed, a NIOSH/MSHA aproved air supplied respirator or dust respirator is advised.
Exposure Effects
Irritation. Possible allergic reation to dust. May cause dryness of mouth, increased thirst, irregular heartbeat, mood changes, muscle cramps, pain, nausea, vomiting, tiredness, weakness, weak pulse.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks
Wear approved protective equipment. Vacuum or sweep up spill. Avoid dust creation. Place spillage in appropriate container for disposal.

Stability and Reactivity

Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Toxic fumes.
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