Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
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(+)-4-Amino-10-methylfolic acid(59-05-2)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
(+)-4-Amino-10-methylfolic acid
Synonyms
2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioic acid
4-Amino-10-methylfolic acid
4-Amino-4-deoxy-N(10)-methylpteroylglutamate
4-Amino-4-deoxy-N(10)-methylpteroylglutamic acid
Amethopterin
Amethopterine
CAS
59-05-2
Formula
C20H22N8O5
Molecular Weight
454.45
EINECS
200-413-8
RTECS
MA1225000
RTECS Class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant
Merck
12,6065
Beilstein/Gmelin
70669
Beilstein Reference
4-26-00-03833

Physical and Chemical Properties

Appearance
Odorless yellow to orange-brown crystalline powder.
Solubility in water
insoluble
Melting Point
195
pKa/pKb
3.54 (pKa)
Partition Coefficient
-.28
Usage
Antimetabolite.

First Aid Measures

Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation
Get medical aid immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage
Deep freeze (below -20 C). Keep containers tightly closed. Store protected from moisture. Store protected from light.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Store protected from light. Use only in a chemical fume hood. Keep from contact with moist air and steam.

Hazards Identification

Inhalation
May cause effects similar to those described for ingestion.
Skin
Not available. Causes skin irritation, rashes, itching, dermatitis, photosensitivity, discoloration of the skin, acne, burning and hair loss.
Eyes
Causes eye irritation.
Ingestion
Harmful if swallowed. Ingestion may result in irritation of the esophagus, bleeding of the stomach and ulcer formation. May cause headaches, drowsiness, anorexia, blurred vision, eye discomfort, ringing in the ears, fatigue, dizziness, gingivitis, diarrhea, hair loss, cerebrospinal fluid effects, blood pressure depression, and cyanosis. May cause blood cell counts to decrease. People with preexisting liver or kidney malfunctions are at increased risk from this substance. Liver dysfunction is usually reversible, but may lead to cirrhosis.
Hazards
Contact with metals may evolve flammable hydrogen gas.
UN (DOT)
2811

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Exposure Effects
behavioral abnormalities, abnormal reflexes, and focal sensorimotor signs may occur following second or third dose of high-dose methotrexate. Acute or subacute neurologic toxicity may occur following intrathecal methotrexate. Parenteral or oral administration is unlikely to cause neurological damage.
Poison Class
1*

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. To extinguish fire, use carbon dioxide, dry chemical powder or appropriate foam.
Fire Potential
This material is probably combustible.

Accidental Release Measures

Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Provide ventilation.

Stability and Reactivity

Stability
Stable at room temperature in closed containers under normal storage and handling conditions. Decomposes on exposure to light.
Incompatibilities
Strong oxidizing agents, strong acids, moisture, direct light.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.
Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number
2811
Hazard Class
6.1
Packing Group
I; II; III
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