Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
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Edaravone(89-25-8)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
Edaravone
Synonyms
1,2-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
1-Phenyl-3-methyl-2-prazolin-5-one
3-Methyl-1-phenylpyrazolin-5(4H)-one
5-Methyl-2-phenyl-1H-pyrazol-3-one
Synonyms
3-Methyl-1-phenyl-2-pyrazolin-5-one
5-Methyl-2-phenyl-1H-pyrazol-3-one
N-Demethylantipyrine
CAS
19735-89-8
CAS
89-25-8
Formula
C10H10N2O
Molecular Weight
174.2
EINECS
201-891-0
EINECS
243-261-8
RTECS
UQ9625000
RTECS Class
Tumorigen; Drug; Mutagen; Reproductive Effector; Primary Irritant
Merck
12,6809
Beilstein/Gmelin
140723
Beilstein/Gmelin
609575
Beilstein Reference
4-24-00-00071

Physical and Chemical Properties

Appearance
White to off-white crystals or powder.
Appearance
White to off-white powder or crystals.
Solubility in water
3 g/L
Solubility in water
Slightly soluble
Melting Point
126
Melting Point
127 - 128
Boiling Point
276
Boiling Point
287
Vapor Pressure
<0.01
Vapor Pressure
0.005 (25 C)
Density
1.120 g/cm3 (20 C)
Density
1.26 g/cm3 (20 C)
pKa/pKb
13.21 (pKb)
pKa/pKb
11.68 (pKb)
Partition Coefficient
.44
Heat Of Vaporization
51.5 kJ/mol
Heat Of Vaporization
57.6 kJ/mol
Usage
Intermediate for dyes & drugs, sensitive reagent for detection of cyanide.
Refractive Index
0.00014 (25 C)
Refractive Index
1.637

First Aid Measures

Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.
Storage
Store in an explosion proof refrigerator.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light.

Hazards Identification

Ingestion
May cause irritation of the digestive tract.
Ingestion
Moderately toxic.
Inhalation
May cause respiratory tract irritation.
Inhalation
Causes irritation.
Skin
Causes irritation.
Skin
May cause skin irritation.
Eyes
Causes irritation.
Eyes
Causes mild eye irritation.
EC Safety Phrase
S 22 24/25

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Poison Class
4

Fire Fighting Measures

Flash Point
121
Flash Point
155
Fire Fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire, use carbon dioxide, dry chemical powder or appropriate foam.
Fire Potential
This material is probably combustible.

Accidental Release Measures

Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. Cover with dry earth, dry sand, or other non-combustible material followed with plastic sheet to minimize spreading and contact with water.
Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Disposal Code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, oxides of nitrogen, carbon dioxide.

Transport Information

HS Code
2933 19 90
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