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o-Anisidine(90-04-0)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
o-Anisidine

Synonyms
2-Aminoanisole
2-Methoxyaniline
2-Methoxybenzenamine
o-Methoxyaniline

CAS
90-04-0

Formula
C7H9NO

Molecular Weight
123.16

EINECS
201-963-1

RTECS
BZ5410000

RTECS Class
Tumorigen; Mutagen

Merck
13,670

Beilstein/Gmelin
386210

Beilstein Reference
4-13-00-00806

EC Index Number
612-035-00-4

EC Class
Carcinogenic Category 2; Mutagenic Category 3; Toxic

Physical and Chemical Properties

Appearance
Red or yellow oily liquid with an amine-like odor becomes brownish on exposure to air.

Solubility in water
Slightly soluble

Melting Point
5

Boiling Point
225

Vapor Pressure
0.09 (25 C)

Density
0.966 g/cm3 (13 C)

pKa/pKb
9.48 (pKb6

Partition Coefficient
1.18

Heat Of Vaporization
46.2 kJ/mol

Heat Of Combustion
-3995 kJ/mol

Usage
Intermediate in the manufacturing of dyes, pharmaceuticals, and fragrances.

Vapor Density
4.25

Saturation Concentration
131.6 ppm (0.013%) at 27 C (calculated)

Refractive Index
1.5688 (20 C)

Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen.

Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if symptoms occur.

Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage
Store in a cool, dry place. Store in a tightly closed container.

Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get on skin or in eyes. Do not ingest or inhale.

Hazards Identification

Inhalation
May cause severe allergic respiratory reaction. May cause respiratory tract irritation.

Skin
May be absorbed through the skin in harmful amounts. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. If absorbed, may cause symptoms similar to those for ingestion.

Eyes
Causes severe eye irritation.

Ingestion
May cause irritation of the digestive tract. May cause kidney damage. May cause methemoglobinemia, cyanosis, convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood.

Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase
R 45 68 23/24/25

EC Safety Phrase
S 53 45

UN (DOT)
2431

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects
May cause cancer according to animal studies.

Exposure limit(s)
NIOSH REL: Ca 0.5 mg/m3 skin See Appendix A NIOSH IDLH: Potential occupational carcinogen 50 mg/m3

Poison Class
1*

Fire Fighting Measures

Flash Point
100

Autoignition
437

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Fire Potential
This chemical is combustible.