Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
Home > 3,7,12-Trioxo-5beta-cholan-24-oic acid > 3,7,12-Trioxo-5beta-cholan-24-oic acid(81-23-2)

3,7,12-Trioxo-5beta-cholan-24-oic acid(81-23-2)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
3,7,12-Trioxo-5beta-cholan-24-oic acid
Synonyms
3,7,12-Triketocholanic acid
3,7,12-Trioxocholan-24-oic acid, (5b)-
3,7,12-Trioxocholanic acid
Cholepatin
Oxycholin
Triketocholanic acid
CAS
81-23-2
Formula
C24H34O5
Molecular Weight
402.53
EINECS
201-335-7
RTECS
FZ2300000
RTECS Class
Drug
Merck
13,2888
Beilstein/Gmelin
3226734
Beilstein Reference
4-10-00-03478

Physical and Chemical Properties

Appearance
Off-white crystals.
Solubility in water
Slightly soluble
Melting Point
242
Density
1.196 g/cm3
pKa/pKb
4.74 (pKa)
Partition Coefficient
4.01
Usage
Acts as a hydrocholeretic, increasing bile output to clear increased bile acid load.

First Aid Measures

Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage
Store in a tightly closed container. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Ingestion
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Skin
May cause skin irritation.
Eyes
May cause eye irritation.
EC Safety Phrase
S 22 24/25

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities
Oxidizing agents.
Stability
Stable under normal temperatures and pressures.
Decomposition
Carbon monoxide, carbon dioxide, acrid smoke and fumes.
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