Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
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3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin(81-81-2)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin
Synonyms
2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)
2-Hydroxy-3-(3-oxo-1-phenylbutyl)chromen-4-one
3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
Coumafene
Prothromadin
CAS
81-81-2
Formula
C19H16O4
Molecular Weight
308.33
EINECS
201-377-6
RTECS
GN4550000
RTECS Class
Agricultural Chemical and Pesticide; Reproductive Effector; Human Data
Merck
12,10174
Beilstein/Gmelin
1293536
Beilstein Reference
5-18-04-00162
EC Index Number
607-056-00-0
EC Class
Toxic for reproduction Category 1; Toxic; Dangerous for the Environment

Physical and Chemical Properties

Appearance
Colorless crystals.
Solubility in water
20 mg/L
Melting Point
167 - 168
Boiling Point
515
Vapor Pressure
2E-11 (25 C)
pKa/pKb
4.50 (pKa)
Partition Coefficient
2.52
Heat Of Vaporization
82.9 kJ/mol
Usage
Rodenticide for norway rats & for house mice.
Vapor Density
10.6

First Aid Measures

Ingestion
Seek medical assistance.
Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
Skin
Remove and isolate contaminated clothing and shoes. Remove material from skin immediately. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
Eyes
Immediately flush with running water for at least 20 minutes.

Handling and Storage

Storage
Store at away from heat and open flame. Do not store near feeds and foodstuffs and keep away from children, domestic animals, pets, or wildlife.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Effects of contact or inhalation may be delayed.
Skin
Warfarin may be absorbed through the skin and cause systemic poisoning.
Eyes
See Inhalation.
Ingestion
Abdominal pain, vomiting, gastrointestinal bleeding, hemoptysis, and bloody or melenotic stools may occur.
Hazards
Contact with strong oxidizers may cause fires and explosions. Toxic gases and vapors (e.g., carbon monoxide) may be released in heating to decomposition. Avoid strong oxidizers.
UN (DOT)
3027

Exposure Controls/Personal Protection

Personal Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Exposure Effects
Intracranial hemorrhage and hematomyelia may occur following warfarin therapy. The use of warfarin during pregnancy has been associated with teratogenic effects. <br>Fetal intraventricular hemorrhage has been reported following maternal ingestion of warfarin. <br>Craniofacial, musculoskeletal, skin, eye, gastrointestinal, and cardiovascular developmental abnormalities have been observed in the offspring of women administered warfarin sodium during pregnancy. <br>Intrauterine fetal demise, intrauterine growth retardation, and hemorrhagic disease of the newborn have been reported following administration of warfarin sodium to pregnant women.
Exposure limit(s)
TLV: ppm; 0.1 mg/m3 (as TWA) (ACGIH 1991-1992). OSHA PEL: TWA 0.1 mg/m3 NIOSH REL: TWA 0.1 mg/m3 NIOSH IDLH: 100 mg/m3
Poison Class
2

Fire Fighting Measures

Flash Point
188
Fire Fighting
(Non-Specific -- Poison B Solid) Wear full protective clothing and self-contained breathing apparatus.(Non-Specific -- Poison B Solid) Extinguish fire using agent suitable for type of surrounding fire. Use alcohol foam, carbon dioxide, or dry chemical.
Fire Potential
Contact with strong oxidizers may cause fires and explosions.

Accidental Release Measures

Small spills/leaks
Do not touch spilled material. Eating and smoking should not be permitted in areas where it is handled, processed or stored. For small spills: sweep onto paper or other suitable material. Place in an appropriate container and burn in a safe place. Large quantities may be destroyed by dissolving in a flammable solvent (e.g., alcohol) and atomizing in a combustion chamber.

Stability and Reactivity

Stability
Contact with strong oxidizers may cause fires and explosions.
Incompatibilities
Incompatible with the following: Strong oxidizers.
Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number
3027
Hazard Class
6.1
Packing Group
I; II; III
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