Sulfonamide name
Chinese name sulfanilamide
The English name is sulfanilamide
Chinese nickname for aminobenzene sulfonamide | the azole lu | 4 - aminobenzene sulfonamide | crystalline sulfanilamide
More English nicknames
Sulfonamide bioactivity
Sulfanilamide is a bacterial dihydrosphenic acid synthetase inhibitor with an IC50 of 320 μM.
Related category
Signal path > > Anti-infection > > bacteria
Research Field > > infection
Reference literature
[1]. McCullough, J.L. and T.H. Maren, Inhibition of dihydropteroate synthetase from Escherichia coli by sulfones and sulfonamides. Antimicrob Agents Chemother, 1973. 3(6): p. 665-9.
[2]. Meneau, I., et al., Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae. Antimicrob Agents Chemother, 2004. 48(7): p. 2610-6.
[3]. Hughes, W.T. and J. Killmar, Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother, 1996. 40(4): p. 962-5.
Physical and chemical properties of sulfonamide
Density 1.4± 0.1g /cm3
Boiling point 400.5±47.0 °C at 760 mmHg
Melting point 164-166 °C(lit.)
Molecular formula C6H8N2O2S
Molecular weight 172.205
Flash point 196.0±29.3 °C
Exact mass 172.030655
PSA 94.56000
LogP minus 0.72
Appearance properties white to light yellow crystalline powder
Vapor pressure 0.0±0.9 mmHg at 25°C
Refractive index 1.628
Storage condition
1. In a cool, ventilated and dry place, prevent heat, sun protection and moisture. Store and transport in accordance with general chemical regulations.
2. Use lining plastic bag to cover the sack, or lining plastic bag, middle layer with kraft paper bag, coat fiber cloth bag packaging. Generally each bag 40kg. Store in a cool, ventilated, dry place, heat, sunscreen, moisture-proof. Store and transport in accordance with general chemical regulations.
stability
It can be used as medicine and has an inhibitory effect on the growth and reproduction of bacteria. In large doses, sulfonamide can cause death due to a loss of balance between absorption and excretion. Dog transoral LD50:2000mg/kg. A large amount of sulfanilamide can cause hypoxia, nausea, vomiting, diarrhea and other side effects, affect the liver and kidney, can also cause tinnitus, vertigo, headache, and even a variety of mental symptoms, until death. Operators should wear protective equipment.
Water solubility 7.5g /L at 25 ºC
Molecular structure
1. Molar refractive index: 42.80
2, molar volume (cm3/mol) : 120.6
3. Isotropic specific volume (90.2K) : 340.9
4. Surface tension (dyne/cm) : 63.7
5. Polarization (10-24cm3) : 16.97
Computational chemistry
1. Reference value for calculating hydrophobic parameters (XlogP) : None
2. Number of hydrogen bond donors :2
3. Number of hydrogen bond receptors :4
4. Number of rotatable bonds :1
5. Number of tautomers: None
6. Topological molecular polar surface area 94.6
7. Number of heavy atoms :11
8. Surface charge :0
9. Complexity :211
10. Number of isotope atoms :0
11. Determine the number of primary constitutive centers :0
12. Number of indeterminate atomic orthotropic centers :0
13. Determine the number of chemical bond constitutive centers :0
14. Number of uncertain bond constitutive centers :0
15. Number of covalent bond units :1
more
1. Properties: White granular or powdered crystal, odorless, slightly bitter taste.
2. Density (g/mL,25/4℃) : 1.08
3. Relative vapor density (g/mL, air =1) : uncertain
4. Melting point (ºC) : 165~166
5. Boiling point (ºC, atmospheric pressure) : Uncertain
6. Boiling point (ºC, 5.2kPa) : Uncertain
7. Refractive index: uncertain
8. Flash point (ºC) : Uncertain
9. Specific rotation (º) : Uncertain
10. Spontaneous ignition point or ignition temperature (ºC) : uncertain
11. Vapor pressure (kPa,25ºC) : Uncertain
12. Saturated vapor pressure (kPa,60ºC) : Uncertain
13. Heat of combustion (KJ/mol) : uncertain
14. Critical temperature (ºC) : Uncertain
15. Critical pressure (KPa) : Uncertain
16. The opposite value of the oil-water (octanol/water) partition coefficient: uncertain
17. Upper explosion limit (%,V/V) : Uncertain
18. Lower explosive limit (%,V/V) : Uncertain
19 Solubility: slightly soluble in cold water, ethanol, methanol, ether and acetone, easily soluble in boiling water, glycerin, hydrochloric acid, potassium hydroxide and sodium hydroxide solution, insoluble in chloroform, ether, benzene, petroleum ether.
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