Product description:
Comfortable more sodium glucose (SugammadexSodiumInjection), commodity called britt pavilion (Bridion), is developed by Merck the specificity of the world's first and only combining drugs neuromuscular blockade antagonism. It is a modified γ-cyclodextrin that antagonizes rocuronium or vecuronium induced neuromuscular block by forming a complex in plasma with the neuromuscular blockers Rocuronium or vecuronium, thereby reducing the number of neuromuscular blockers that bind to nicotinic receptors at the neuromuscular junction.
Main role:
Sodium sulgamose plays this role because of its gamma-cyclodextrin molecular structure, which can form a complex with rocuronium to reduce the concentration of free drugs in the blood, thus reversing the neuromuscular blocking effect of Rocuronium.
Preparation:
Sodium hydride (706g, 60%) was added to dry DMF(31.2L) under nitrogen and ice bath. At 0-10 ℃, the mixture of three p-Tolyphosphine (172g) -3-mercaptopropionic acid (938g)-DMF(1.2L) was slowly added, and then the mixture of all iodogama-cyclodextrin (1.2kg) -trip-tolyphosphine (45g)-DMF(6.25L) was stirred at the temperature of 65-75 ℃. Continue stirring and react for about 4h. The reaction liquid was reduced to 0 ~ 10℃, water (6L) was added, and the reaction was heated to 55 ~ 70℃ under stirring for about 2h. The reaction liquid was cooled to room temperature, pumped and filtered, the filter cake was dissolved with water (9.6L), filtered with diatomaceous earth, and then added ethanol (24L) into the filtrate, pumped and filtered to obtain the crude sodium Sugannuglucose (1.1kg, yield 92%, purity 91.35%).
Purification method:
Step 1: Pretreatment of activated carbon under nitrogen protection, take 5 grams of SHIRASAGIA activated carbon and add 100ml purified water into 250ml three-mouth bottle, which is equipped with mechanical stirring and vacuum device. After stirring, the vacuum is replaced with nitrogen to maintain the nitrogen atmosphere, and the water/activated carbon mixture in the bottle is heated to boiling. Allow to boil for 0.5 hours, then remove from the heat and cool to room temperature. The filter cake obtained by nitrogen pressure filtration is the pre-treated activated carbon, which is filled with nitrogen and stored for use.
Step 2: Purification of crude sodium Sugen Add 10g of crude sodium Sugen into 250ml three-way bottle, dissolve in 50ml of newly boiled cold water, under nitrogen protection, add 1g of pre-treated special egret (TOKUSEISHIRASAGI) activated carbon prepared in example 1, stir and adsorb for 2 hours. After the activated carbon was filtered out, the obtained aqueous solution was concentrated to obtain 9.2g of sodium sulgenose with a purity of 100.0% (sodium sulgenose + sodium monohydroxy sulgenose).
Our advantages:
1) Timely communication, reply within 12 hours.You can leave any messages on our whatsapp or send email to us.
2)Selecting raw materials strictly,our products are the highest purity.
3)Reasonable and competitive price.
4) Free sample for your evaluation.Customers only need to undertake the shipping fee for delivery the samples to your destionation.
5)OEM/ODM Available.Trial order is available for testing after samples.
6) Packaging can be customized according to each buyers' special request.
We guarantee that your package will pass 100% through the Mexico US, UK, Australia, Netherlands, Canada, France, Germany, Spain, Belgium, Sweden, Poland, Russian, Ukraine, Kazakhstan, Czech Republic, Slovakia, Portugal.
We have freight forwarders in these countries, and our customs clearance company will clear your parcels without any customs issues, sometimes even 1000 kg. Door to door service. Make sure you receive 100% of the goods. Let you have a good experience of our strong freight capacity.
Company Introduction
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!
After Sales Service
1) Best quality in your requirement
2)Competitive price in china market
3)Mature technical support
4)Professional logistic support
5 )Full experience of large numberscontainers loading in chinese sea port
6 )Fast shipment by reputed shipping line
7) Packing with pallet as buyer's special request
8) Best service after shipment.
9) Cargoes together with container after-sales service available
10) Full experience in export
11)Raw materials from chinese origin
FAQ
What is the way you ship?
Express: FedEx, UPS, EMS, DHL, USPS, TNT, DPD, Aramex etc
Our way of shipping the products is universal and secure.
The company name and other contents related to pharmacy are not written on the package slips.
The way of packing is regularly changed for a secure delivery.
The packages are small in order to avoid unwelcomed questions . If the order is big, then it will be divided into two or more packages
Can the packages be trackable?
YES, we provide tracking number and you can track on internet.
Where do you ship to?
Worldwide.
Do you offer domestic shipping/remail shipping?
Yes we can ship to USA/UK/Canada/Australia/Germany etc warehouse first then to you.
Do you ensure your packing , what about customs, what happens if the package is retained?
We concern a lot about our safety system, we pack the orders as secure as possible. If a package is seized at customs, reships of seized orders will be done provided you have a copy of the letter to show us. If you receive a seizure letter, please contact us immediately with a scanned copy of the seizure letter, and also a new address to have your order reshipped to.
Which payment options are available?
Bitcoin
Western Union
Bank wire
MoneyGram
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